Literature summary for 2.7.7.1 extracted from

Mao, X.R.; Kaufman, D.M.; Crowder, C.M.
Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response (2016), Cell Death Dis., 7, e2113.

Cloned(Commentary)

Cloned (Comment)	Organism
gene Nmnat1, recombinant expression of mouse Nmnat1 non-nuclear-localized gain-of-function mutant gene (m-nonN-Nmnat1) in Caenorhabditis elegans. The transgenic enzyme provides protection from both hypoxia-induced animal death and taxol-induced axonal pathology and significantly lengthens the nematode's lifespan. Loss of function in two genes, haf-1 and dve-1, encoding mitochondrial unfolded protein response (mitoUPR) factors are identified as suppressors. M-nonN-Nmnat1 induces a transcriptional reporter of the mitoUPR gene hsp-6 and provides protection from the mitochondrial proteostasis toxin ethidium bromide. M-nonN-Nmnat1 is also protective against axonal degeneration in Caenorhabditis elegans induced by the chemotherapy drug taxol. Taxol markedly reduces basal expression of a mitoUPR reporter, the expression is restored by m-nonN-Nmnat1	Mus musculus

Cloned (Comment)

Organism

gene Nmnat1, recombinant expression of mouse Nmnat1 non-nuclear-localized gain-of-function mutant gene (m-nonN-Nmnat1) in Caenorhabditis elegans. The transgenic enzyme provides protection from both hypoxia-induced animal death and taxol-induced axonal pathology and significantly lengthens the nematode's lifespan. Loss of function in two genes, haf-1 and dve-1, encoding mitochondrial unfolded protein response (mitoUPR) factors are identified as suppressors. M-nonN-Nmnat1 induces a transcriptional reporter of the mitoUPR gene hsp-6 and provides protection from the mitochondrial proteostasis toxin ethidium bromide. M-nonN-Nmnat1 is also protective against axonal degeneration in Caenorhabditis elegans induced by the chemotherapy drug taxol. Taxol markedly reduces basal expression of a mitoUPR reporter, the expression is restored by m-nonN-Nmnat1

Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9EPA7	gene Nmnat1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
hippocampus	-	Mus musculus	-
neuron	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
m-nonN-Nmnat1	-	Mus musculus
nicotinamide mononucleotide adenylyltransferase	-	Mus musculus
nicotinamide mononucleotide adenylyltransferase type 1	-	Mus musculus
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	UniProt	Mus musculus
NMNAT1	-	Mus musculus
non-nuclear-localized-Nmnat1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1, Nmnat1, produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury, the mechanism involves the mitochondrial unfolded protein response (mitoUPR) factor, penotype, overview	Mus musculus