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Literature summary for 2.7.7.1 extracted from

  • Ali, Y.O.; Ruan, K.; Zhai, R.G.
    NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy (2012), Hum. Mol. Genet., 21, 237-250.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
nicotinamide mononucleotide adenylyltransferase
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Drosophila melanogaster
NMNAT
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Drosophila melanogaster

General Information

General Information Comment Organism
physiological function the enzyme has both NAD synthase and chaperone function. The enzyme is essential for maintaining neuronal integrity under normal conditions and protects against several neurodegenerative conditions. Enzyme overexpression significantly suppresses both behavioral and morphological deficits associated with tauopathy by means of reducing the levels of hyperphosphorylated tau oligomers and rescueing age-dependent vacuolization induced by tau expression. The enzyme interacts with phosphorylated tau in vivo and promotes the ubiquitination and clearance of toxic tau species. Apoptosis activation is significantly reduced in brains overexpressing the enzyme, and neurodegeneration is suppressed Drosophila melanogaster