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Literature summary for 2.7.7.1 extracted from

  • Raffaelli, N.; Lorenzi, T.; Emanuelli, M.; Amici, A.; Ruggieri, S.; Magni, G.
    Nicotinamide-mononucleotide adenylyltransferase from Sulfolobus solfataricus (2001), Methods Enzymol., 331, 281-292.
    View publication on PubMed
Search for more literature for 2.7.7.1

Activating Compound

Activating Compound Comment Organism Structure
SO42-
-
 Saccharolobus solfataricus

General Stability

General Stability Organism
chaotropic anions are strong destabilizers of the enzyme Saccharolobus solfataricus
dithiothreitol has no effect up to 50°C but destabilizes the enzyme at higher temperatures Saccharolobus solfataricus
increasing ionic strenght of NaCl and KCl stabilizes the thermal stability of the enzyme Saccharolobus solfataricus

Metals/Ions

Metals/Ions Comment Organism Structure
KCl
-
 Saccharolobus solfataricus
Mg2+
-
 Saccharolobus solfataricus
Na+
-
 Saccharolobus solfataricus
NH4+
-
 Saccharolobus solfataricus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18600
-
 x * 18600, SDS-PAGE Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharolobus solfataricus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.8
-
 purification step: TSK phenyl-5PW Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Saccharolobus solfataricus diphosphate + NAD+
-
 r

Subunits

Subunits Comment Organism
? x * 18600, SDS-PAGE Saccharolobus solfataricus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37 97 activity shows a continuous increase up to 97°C Saccharolobus solfataricus