Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.6.5 extracted from

  • Fehr, S.; Richter, D.
    Stringent response of Bacillus stearothermophilus: evidence for the existence of two distinct guanosine 3,5-polyphosphate synthetases (1981), J. Bacteriol., 145, 68-73.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.6.5

Activating Compound

Activating Compound Comment Organism Structure
additional information (p)ppGpp synthetase II does not Geobacillus stearothermophilus
mRNA (p)ppGpp synthetase II does not Geobacillus stearothermophilus

Inhibitors

Inhibitors Comment Organism Structure
tetracycline not (p)ppGpp synthetase II Geobacillus stearothermophilus
Thiostrepton not (p)ppGpp synthetase II Geobacillus stearothermophilus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 ATP synthetase II, pH 7.8, 37°C Geobacillus stearothermophilus
2
-
 ATP synthetase I, pH 7.8, 37°C Geobacillus stearothermophilus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol (p)ppGpp synthetase II Geobacillus stearothermophilus 5829
-
ribosome (p)ppGpp synthetase I Geobacillus stearothermophilus 5840
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74000
-
 synthetase II, sucrose density gradient centrifugation Geobacillus stearothermophilus
86000
-
 synthetase I, sucrose density gradient centrifugation Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Geobacillus stearothermophilus
-
 AMP + guanosine 3'-diphosphate 5'-triphosphate
-
 ?
additional information Geobacillus stearothermophilus (p)ppGpp synthetase II is responsible for (p)ppGpp accumulation during carbon source downshift ?
-
 ?

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
 2 different enzymes: (p)ppGpp synthetase I, (p)ppGpp synthetase II
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP
-
 Geobacillus stearothermophilus AMP + guanosine 3'-diphosphate 5'-triphosphate
-
 ?
additional information (p)ppGpp synthetase II is responsible for (p)ppGpp accumulation during carbon source downshift Geobacillus stearothermophilus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Geobacillus stearothermophilus