Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | (p)ppGpp synthetase II does not | Geobacillus stearothermophilus | |
mRNA | (p)ppGpp synthetase II does not | Geobacillus stearothermophilus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tetracycline | not (p)ppGpp synthetase II | Geobacillus stearothermophilus | |
Thiostrepton | not (p)ppGpp synthetase II | Geobacillus stearothermophilus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
ATP | synthetase II, pH 7.8, 37°C | Geobacillus stearothermophilus | |
2 | - |
ATP | synthetase I, pH 7.8, 37°C | Geobacillus stearothermophilus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | (p)ppGpp synthetase II | Geobacillus stearothermophilus | 5829 | - |
ribosome | (p)ppGpp synthetase I | Geobacillus stearothermophilus | 5840 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
74000 | - |
synthetase II, sucrose density gradient centrifugation | Geobacillus stearothermophilus |
86000 | - |
synthetase I, sucrose density gradient centrifugation | Geobacillus stearothermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | Geobacillus stearothermophilus | - |
AMP + guanosine 3'-diphosphate 5'-triphosphate | - |
? | |
additional information | Geobacillus stearothermophilus | (p)ppGpp synthetase II is responsible for (p)ppGpp accumulation during carbon source downshift | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Geobacillus stearothermophilus | - |
2 different enzymes: (p)ppGpp synthetase I, (p)ppGpp synthetase II | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | - |
Geobacillus stearothermophilus | AMP + guanosine 3'-diphosphate 5'-triphosphate | - |
? | |
additional information | (p)ppGpp synthetase II is responsible for (p)ppGpp accumulation during carbon source downshift | Geobacillus stearothermophilus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Geobacillus stearothermophilus |