Literature summary for 2.7.6.1 extracted from

Cherney, M.M.; Cherney, L.T.; Garen, C.R.; James, M.N.
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs (2011), J. Mol. Biol., 413, 844-856.

Search for more literature for 2.7.6.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Thermoplasma volcanium

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with its substrate D-ribose 5-phosphate and with substrate analogs beta,gamma-methylene ATP and ADP, hanging drop vapor diffusion method, using 2 M ammonium sulfate, pH 4.0 or 30% (w/v) polyethylene glycol 600, pH 7.5	Thermoplasma volcanium

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Thermoplasma volcanium

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	gel filtration	Thermoplasma volcanium

Organism

Organism	UniProt	Comment	Textmining
Thermoplasma volcanium	Q97CA5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-ribose 5-phosphate	-	Thermoplasma volcanium	AMP + 5-phospho-alpha-D-ribose 1-diphosphate	-	ir

Synonyms

Synonyms	Comment	Organism
phosphoribosyl pyrophosphate synthetase	-	Thermoplasma volcanium
PRPP synthetase	-	Thermoplasma volcanium

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Release 2023.1 (January 2023)