Literature summary for 2.7.6.1 extracted from

Becker, M.A.; Taylor, W.; Smith, P.R.; Ahmed, M.
Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase (1996), J. Biol. Chem., 271, 19894-19899.

Search for more literature for 2.7.6.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoenzymes PRSI and PRSII in Escherichia coli	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast cell line	initiated from normal skin biopsies	Homo sapiens	-
lymphoblast	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
20.5	21.2	values from lymphoblasts extracts from normal and PRS catalytic superactivity affected patients	Homo sapiens
22.2	29.9	values from fibroblast extracts from normal and PRS catalytic superactivity affected patients	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)