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Literature summary for 2.7.4.9 extracted from
- Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase (2004), Mini Rev. Med. Chem., 4, 351-359.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | potential targets for the development of antiviral and cancer therapies | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dTMP | Homo sapiens | involved in TTP metabolism, required for the activation of clinically relevant thymidine analogs such as anti-HIV and anti-cancer prodrugs | ADP + dTDP | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dTMP | - |
Homo sapiens | ADP + dTDP | - |
? | |
| ATP + dTMP | involved in TTP metabolism, required for the activation of clinically relevant thymidine analogs such as anti-HIV and anti-cancer prodrugs | Homo sapiens | ADP + dTDP | - |
? | |
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