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Literature summary for 2.7.4.9 extracted from

  • Smith, L.K.; Eakin, R.E.
    Partial purification and characterization of thymidylate kinase from embryonic chick liver (1975), Arch. Biochem. Biophys., 167, 61-71.
    View publication on PubMed

General Stability

General Stability Organism
the enzyme is very labile and can be stabilized for long periods of time by its substrate thymidine 5'-monophosphate in the presence of 2-mercaptoethanol Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
ADP 25% inhibition Gallus gallus
dATP 0.4 mM, 12% inhibition, adult liver Gallus gallus
dTDP 0.4 mM, 48% inhibition Gallus gallus
dTTP 0.4 mM, 43% inhibition Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement of a Mg2+:ATP ratio greater than 1.0 and for optimal activity there is a requirement of an additional 2-3 mM Mg2+ above the concentration of ATP Gallus gallus
Mn2+ can partially replace Mg2+ requirement Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
gel filtration Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver embryonic and adult Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.188
-
-
Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Gallus gallus