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Literature summary for 2.7.4.7 extracted from

  • Nodwell, M.B.; Menz, H.; Kirsch, S.F.; Sieber, S.A.
    Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis (2012), ChemBioChem, 13, 1439-1446.
    View publication on PubMed
Search for more literature for 2.7.4.7

Inhibitors

Inhibitors Comment Organism Structure
(6R)-6-[(2E)-4-oxo-6-phenylhex-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one lactone isolated from Cryptocarya rugulosa, covalent inhibition Staphylococcus aureus
(6R)-6-[(2E)-6-(4-ethynylphenyl)-4-oxohex-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one derivative of a lactone isolated from Cryptocarya rugulosa, covalent inhibition Staphylococcus aureus
(6S)-6-[(2E)-6-(4-ethynylphenyl)-4-oxohex-2-en-1-yl]tetrahydro-2H-pyran-2-one derivative of a lactone isolated from Cryptocarya rugulosa, covalent inhibition Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus P66915 bifunctional hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
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IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.014
-
 pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus (6R)-6-[(2E)-6-(4-ethynylphenyl)-4-oxohex-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one
0.025
-
 pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus (6R)-6-[(2E)-4-oxo-6-phenylhex-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one
0.032
-
 pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus (6S)-6-[(2E)-6-(4-ethynylphenyl)-4-oxohex-2-en-1-yl]tetrahydro-2H-pyran-2-one