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Literature summary for 2.7.4.34 extracted from
- Establishing Virulence Associated Polyphosphate Kinase 2 as a drug target for Mycobacterium tuberculosis (2016), Sci. Rep., 6, 26900 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | O05877 | - |
- |
| Mycobacterium tuberculosis ATCC 25618 | O05877 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| polyphosphate:GDP phosphotransferase | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PPK2 contributes to Mycobacterium tuberculosis ability to cause disease in guinea pigs. PPK2 mutant-infected guinea pigs have significantly reduced bacterial loads and tissue pathology in comparison to wild-type-infected guinea pigs at later stages of infection. In comparison to the wild-type strain, the PPK2 mutant strain is more tolerant to isoniazid and impaired for survival in THP-1 macrophages | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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