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Literature summary for 2.7.4.34 extracted from

  • Chuang, Y.M.; Belchis, D.A.; Karakousis, P.C.
    The polyphosphate kinase gene ppk2 is required for Mycobacterium tuberculosis inorganic polyphosphate regulation and virulence (2013), mBio, 4, e00039 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
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Mycobacterium tuberculosis ATCC 25618
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Synonyms

Synonyms Comment Organism
Rv3232c
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 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function Ppk2 is required for control of intrabacillary polyphosphate levels and optimal Mycobacterium tuberculosis growth and survival in macrophages and mouse lungs. A Ppk2 insertion mutant has significantly increased polyphosphate content and a 4fold increase in the MIC of isoniazid relative to the wild-type. The mutant shows reduced survival at day 7 in activated and naive J774 macrophages relative to the wild-type. Naive mutant-infected macrophages show increased expression of interleukins IL-2, IL-9, IL-10, IL-12p70, and gamma interferon relative to wild-type-infected macrophages. The mutant exhibits significantly lower lung CFU during acute murine infection Mycobacterium tuberculosis