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Literature summary for 2.7.4.3 extracted from

  • Ionescu, M.I.; Oniga, O.
    Molecular docking evaluation of (E)-5-arylidene-2-thioxothiazolidin-4-one derivatives as selective bacterial adenylate kinase inhibitors (2018), Molecules, 23, 1076 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.3

Inhibitors

Inhibitors Comment Organism Structure
(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
 Escherichia coli
(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
 Streptococcus pneumoniae
(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
 Escherichia coli
(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
 Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Escherichia coli P69441
-
-
Escherichia coli K12 P69441
-
-
Streptococcus pneumoniae Q04ML5 serotype 2
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000497
-
 (5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one closed conformation, pH and temperature not specified in the publication Escherichia coli
0.00213
-
 (5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one closed conformation, pH and temperature not specified in the publication Streptococcus pneumoniae
0.00422
-
 (5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one open conformation, pH and temperature not specified in the publication Streptococcus pneumoniae
0.00468
-
 (5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one closed conformation, pH and temperature not specified in the publication Escherichia coli
0.00592
-
 (5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one closed conformation, pH and temperature not specified in the publication Streptococcus pneumoniae
0.01326
-
 (5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one open conformation, pH and temperature not specified in the publication Escherichia coli
0.03712
-
 (5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one open conformation, pH and temperature not specified in the publication Streptococcus pneumoniae
0.05417
-
 (5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one open conformation, pH and temperature not specified in the publication Escherichia coli