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Literature summary for 2.7.4.3 extracted from

  • Klepinin, A.; Zhang, S.; Klepinina, L.; Rebane-Klemm, E.; Terzic, A.; Kaambre, T.; Dzeja, P.
    Adenylate kinase and metabolic signaling in cancer cells (2020), Front. Oncol., 10, 660 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens P54819
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-

Synonyms

Synonyms Comment Organism
adenylate kinase 2
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Homo sapiens
AK2
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Homo sapiens

General Information

General Information Comment Organism
malfunction adenylate kinase deficiency disrupts cell energetics and causes severe human diseases. Knockdown of overexpressed AK2 in human lung adenocarcinoma cells suppresses proliferation, migration, and invasion as well as induced apoptosis and autophagy Homo sapiens
physiological function adenylate kinase is the critical enzyme in the metabolic monitoring of cellular adenine nucleotide homeostasis. It also directs adenylate kinase/AMP/adenine nucleotide translocase signaling controlling cell cycle and proliferation, and ATP energy transfer from mitochondria to distribute energy among cellular processes. Adenylate kinase 2 and mitochondrial creatine kinase interplay in malignant transformation. Adenylate kinase modulate tumor cell response to survive under oxidative stress Homo sapiens