Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P54819 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
adenylate kinase 2 | - |
Homo sapiens |
AK2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | adenylate kinase deficiency disrupts cell energetics and causes severe human diseases. Knockdown of overexpressed AK2 in human lung adenocarcinoma cells suppresses proliferation, migration, and invasion as well as induced apoptosis and autophagy | Homo sapiens |
physiological function | adenylate kinase is the critical enzyme in the metabolic monitoring of cellular adenine nucleotide homeostasis. It also directs adenylate kinase/AMP/adenine nucleotide translocase signaling controlling cell cycle and proliferation, and ATP energy transfer from mitochondria to distribute energy among cellular processes. Adenylate kinase 2 and mitochondrial creatine kinase interplay in malignant transformation. Adenylate kinase modulate tumor cell response to survive under oxidative stress | Homo sapiens |