Literature summary for 2.7.4.3 extracted from

Thompson, A.A.; Zou, A.; Yan, J.; Duggal, R.; Hao, W.; Molina, D.; Cronin, C.N.; Wells, P.A.
Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity (2009), Biochemistry, 48, 906-916.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in in Sf9 insect cells	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + AMP	in addition to the hydrolysis of NTP and NDP substrates, adenylate kinase activity is detected in purified preparations of nonstructural protein 4B with the reverse reaction ADP + ADP -> ATP + AMP, yielding a larger kcat compared to that of the forward reaction ATP + AMP -> ADP + ADP	Hepacivirus C	ADP + ADP	-	?

Synonyms

Synonyms	Comment	Organism
nonstructural protein 4B	possesses both adenylate kinase activity and nucleotide hydrolase activity	Hepacivirus C
NS4B	-	Hepacivirus C

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Release 2023.1 (January 2023)