Literature summary for 2.7.4.24 extracted from

An, Y.; Jessen, H.J.; Wang, H.; Shears, S.B.; Kireev, D.
Dynamics of substrate processing by PPIP5K2, a versatile catalytic machine (2019), Structure, 27, 1022-1028 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
the Lys248 side chain is rather centered on a position enabling an optimal pulling force applied to the leaving group along the reaction coordinate. The actions of Lys248 pulling forces are influenced by substrate binding. Residue Glu192 makes a specific contribution to the ability of PPIP5K2 to significantly reduce the entropy toll for the catch-and-pass reaction mechanism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43314	isoform PPIP5K2, cf. EC 2.7.4.21	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	i.e. non-natural enantiomer of 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	Homo sapiens	ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate	-	?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate	-	Homo sapiens	ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	-	r

Synonyms

Synonyms	Comment	Organism
PPIP5K2	cf. EC 2.7.4.21	Homo sapiens

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Release 2023.1 (January 2023)