Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.4.24 extracted from

  • Baughman, B.M.; Wang, H.; An, Y.; Kireev, D.; Stashko, M.A.; Jessen, H.J.; Pearce, K.H.; Frye, S.V.; Shears, S.B.
    A High-throughput screening-compatible strategy for the identification of inositol pyrophosphate kinase inhibitors (2016), PLoS ONE, 11, e0164378 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.24

Inhibitors

Inhibitors Comment Organism Structure
UNC10112646 directly inhibits PPIP5K-catalyzed phosphorylation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate to 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate Homo sapiens
UNC10225498 directly inhibits PPIP5K-catalyzed phosphorylation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate to 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43314
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PPIP5K2
-
 Homo sapiens

General Information

General Information Comment Organism
additional information a time-resolved, fluorescence resonance energy transfer ADP-assay is optimized. Inhibition is competitive with ATP Homo sapiens
physiological function the enzyme synthesizes high-energy inositol pyrophosphates, which regulate cell function at the interface between cellular energy metabolism and signal transduction. Inhibition is competitive with ATP Homo sapiens