Literature summary for 2.7.4.24 extracted from

Gu, C.; Nguyen, H.N.; Hofer, A.; Jessen, H.J.; Dai, X.; Wang, H.; Shears, S.B.
The significance of the bifunctional kinase/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis (2017), J. Biol. Chem., 292, 4544-4555 .

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Protein Variants

Protein Variants	Comment	Organism
D332A	2.4-4fold larger net formation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate, but mutation nearly completely impaires its hydrolysis	Homo sapiens
R388A	2.4-4fold larger net formation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate, but mutation nearly completely impaires its hydrolysis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
phosphate	1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate phosphatase activities of PPIP5Ks are 40-90% inhibited by phosphate within the 0-1 mM range; 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate phosphatase activities of PPIP5Ks are 40-90% inhibited by phosphate within the 0-1 mM range	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43314	isoform PPIP5K2	-
Homo sapiens	Q6PFW1	isoform PPIP5K1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme additionally catalyzes the reaction of EC 2.7.4.21, i.e. conversion of 1D-myo-inositol hexakisphosphate to 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward -diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	Homo sapiens	?	-	-

Synonyms

Synonyms	Comment	Organism
PPIP5K1	-	Homo sapiens
PPIP5K2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	levels of both 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate and ATP decrease upon phosphate starvation and subsequently recover during phosphate replenishment	Homo sapiens

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Release 2023.1 (January 2023)