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Literature summary for 2.7.4.21 extracted from

  • Chin, A.; Gao, Z.; Riley, A.; Furkert, D.; Wittwer, C.; Dutta, A.; Rojas, T.; Semenza, E.; Felder, R.; Pluznick, J.; Jessen, H.; Fiedler, D.; Potter, B.; Snyder, S.; Fu, C.
    The inositol pyrophosphate 5-InsP7drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha (2020), Sci. Adv., 6, eabb8542 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q6PD10 isoform IP6K1
-

Synonyms

Synonyms Comment Organism
IP6K1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function product 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate promotes physiological endocytosis and downstream degradation of Na+/K+-ATPase-alpha1. Deletion of IP6K1 elicits a twofold enrichment of Na+/K+-ATPase-alpha1 in plasma membranes of multiple tissues and cell types. 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate binds the RhoGAP domain of phosphatidylinositol 3-kinase (PI3K) p85alpha to disinhibit its interaction with Na+/K+-ATPase-alpha1. This recruits adaptor protein 2 (AP2) and triggers the clathrin-mediated endocytosis of Na+/K+-ATPase-alpha1 Mus musculus