Any feedback?
Literature summary for 2.7.4.21 extracted from
- Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via alpha-actinin and focal adhesion kinase (2017), Proc. Natl. Acad. Sci. USA, 114, 2036-2041 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine | - |
Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q6PD10 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inositol hexakisphosphate kinase 1 | - |
Mus musculus |
| IP6K1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | IP6K1 deletion leads to brain malformation and abnormalities of neuronal migration. IP6K1 deletion disrupts intracellular localization and function of alpha-actinin. The IP6K1 deleted cells display substantial decreases of stress fiber formation and impaired cell migration and spreading. Focal adhesion kinase phosphorylation is substantially decreased in IP6K1 deleted cells | Mus musculus |
| physiological function | the enzyme (IP6K1) physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both focal adhesion kinase and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
