Literature summary for 2.7.4.21 extracted from

Kim, M.G.; Zhang, S.; Park, H.; Park, S.J.; Kim, S.; Chung, C.
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory (2020), Mol. Brain, 13, 72 .

Search for more literature for 2.7.4.21

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q6PD10	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
inositol hexakisphosphate kinase-1	-	Mus musculus
IP6K1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	deletion of inositol hexakisphosphate kinase 1 ( IP6K1) alters probability of presynaptic vesicle release and short-term facilitation of glutamatergic synapses in mouse hippocampus. IP6K1-knockout mice exhibit decreased prepulse inhibition with no defects in Y-maze and elevated plus maze tests. IP6K1 knockout leads to impaired shortterm memory formation in a contextual fear memory retrieval test with no effect on long-term memory. Both hippocampal long-term potentiation and long-term depression in IP6K1-knockout mice are similar to those in the wild-type control	Mus musculus
physiological function	physiological roles of the enzyme (IP6K1) and the associated inositol pyrophosphate metabolism in regulating sensorimotor gating as well as short-term memory	Mus musculus

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Release 2023.1 (January 2023)