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Literature summary for 2.7.4.21 extracted from

  • Zhang, Z.; Liang, D.; Gao, X.; Zhao, C.; Qin, X.; Xu, Y.; Su, T.; Sun, D.; Li, W.; Wang, H.; Liu, B.; Cao, F.
    Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction (2014), Basic Res. Cardiol., 109, 417.
    View publication on PubMed
Search for more literature for 2.7.4.21

Activating Compound

Activating Compound Comment Organism Structure
additional information hypoxia increases IP6Ks activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine inhibiting IP6Ks by the compound decreases 5-diphosphoinositol pentakisphosphate synthesis and increases phosphorylation of Akt at T308 and S473 in mesenchymal stem cells, indicating the downregulation of 5-diphosphoinositol pentakisphosphate expression by IP6K inhibition enhance the activation of Akt in mesenchymal stem cells; inhibiting IP6Ks by the compound decreases 5-diphosphoinositol pentakisphosphate synthesis and increases phosphorylation of Akt at T308 and S473 in mesenchymal stem cells, indicating the downregulation of 5-diphosphoinositol pentakisphosphate expression by IP6K inhibition enhance the activation of Akt in mesenchymal stem cells; inhibiting IP6Ks by the compound decreases 5-diphosphoinositol pentakisphosphate synthesis and increases phosphorylation of Akt at T308 and S473 in mesenchymal stem cells, indicating the downregulation of 5-diphosphoinositol pentakisphosphate expression by IP6K inhibition enhance the activation of Akt in mesenchymal stem cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PD10 isozymes IP6K1; Fluc+-eGFP+ transgenic mice, isozymes IP6K1
-
Mus musculus Q6ZQB6 isozymes IP6K3; Fluc+-eGFP+ transgenic mice, isozymes IP6K3
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Mus musculus Q80V72 isozymes IP6K2; Fluc+-eGFP+ transgenic mice, isozymes IP6K2
-
Mus musculus C57BL/6a Q6PD10 isozymes IP6K1; Fluc+-eGFP+ transgenic mice, isozymes IP6K1
-
Mus musculus C57BL/6a Q6ZQB6 isozymes IP6K3; Fluc+-eGFP+ transgenic mice, isozymes IP6K3
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Mus musculus C57BL/6a Q80V72 isozymes IP6K2; Fluc+-eGFP+ transgenic mice, isozymes IP6K2
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Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stem cell
-
 Mus musculus
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mesenchyme
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 Mus musculus
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Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase
-
 Mus musculus
IP6K
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction selective inhibition of inositol hexakisphosphate kinase enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction. IP6K inhibition may increase Akt activation in mesenchymal stem cells, resulting in enhanced cardiac protective effect after transplantation. Inhibiting IP6Ks by N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine decreases 5-diphosphoinositol pentakisphosphate synthesis and increases phosphorylation of Akt at T308 and S473 in mesenchymal stem cells, indicating the downregulation of 5-diphosphoinositol pentakisphosphate expression by IP6K inhibition enhances the activation of Akt in mesenchymal stem cells. IP6K inhibition by N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine is also associated with decreased apoptosis Mus musculus
physiological function hypoxia increases IP6Ks activity and 5-diphosphoinositol pentakisphosphate production Mus musculus