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Literature summary for 2.7.4.2 extracted from

  • Kudoh, T.; Park, C.S.; Lefurgy, S.T.; Sun, M.; Michels, T.; Leyh, T.S.; Silverman, R.B.
    Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae (2009), Bioorg. Med. Chem., 18, 1124-1134.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information synthesis of a series of C3-substituted mevalonate analogues to probe the steric and electronic requirements off the phosphomevalonate kinase active site for development of specific mechanism-based inhibitors, overview Streptococcus pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (R)-5-phosphomevalonate Streptococcus pneumoniae
-
 ADP + (R)-5-diphosphomevalonate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-5-phosphomevalonate
-
 Streptococcus pneumoniae ADP + (R)-5-diphosphomevalonate
-
 ?
additional information the recombinant enzyme phosphorylates racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues, that are phosphorylated by mevalonate kinase, EC 2.7.1.36, in a first step, overview Streptococcus pneumoniae ?
-
 ?

Synonyms

Synonyms Comment Organism
PMK
-
 Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Streptococcus pneumoniae