BRENDA - Enzyme Database show
show all sequences of 2.7.4.14

Reaction of human UMP-CMP kinase with natural and analog substrates

Pasti, C.; Gallois-Montbrun, S.; Munier-Lehmann, H.; Veron, M.; Gilles, A.M.; Deville-Bonne, D.; Eur. J. Biochem. 270, 1784-1790 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of His-tagged UMP-CMP kinase and UMP-CMP kinase fusion protein with glutathione S-transferase
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
CMP
substrate inhibition above 0.2 mM
Homo sapiens
UMP
substrate inhibition above 0.2 mM
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.022
-
CMP
pH 7.4, 37°C
Homo sapiens
0.044
-
UMP
pH 7.4, 37°C
Homo sapiens
0.045
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.07
-
CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.14
-
UMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.15
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.2
-
CMP
pH 7.4, 37°C
Dictyostelium sp.
0.2
-
UMP
pH 7.4, 37°C
Dictyostelium sp.
0.26
-
ara-CMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.3
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.34
-
ara-CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.9
-
dCMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
1.1
-
dCMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
2
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C
Dictyostelium sp.
2
-
cCMP
pH 7.4, 37°C
Dictyostelium sp.
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + CMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + CDP
-
-
?
ATP + dCMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + dCDP
-
-
?
ATP + UMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + UDP
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Dictyostelium sp.
-
-
-
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ara-CMP
-
645162
Homo sapiens
ADP + ara-CDP
-
-
-
?
ATP + ara-CMP
-
645162
Dictyostelium sp.
ADP + ara-CDP
-
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
645162
Homo sapiens
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine diphosphate
-
-
-
?
ATP + CMP
-
645162
Homo sapiens
ADP + CDP
-
-
-
?
ATP + CMP
-
645162
Dictyostelium sp.
ADP + CDP
-
-
-
?
ATP + CMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + CDP
-
-
-
?
ATP + dCMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + dCDP
-
-
-
?
ATP + L-(-)-2',3'-dideoxy-3'-thia-CMP
-
645162
Dictyostelium sp.
ADP + L-(-)-2',3'-dideoxy-3'-thia-CDP
-
-
-
-
ATP + UMP
-
645162
Homo sapiens
ADP + UDP
-
-
-
?
ATP + UMP
-
645162
Dictyostelium sp.
ADP + UDP
-
-
-
-
ATP + UMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + UDP
-
-
-
?
additional information
the UMP-CMP kinase has a relaxed enantiospecificity for the nucleoside monophosphate acceptor site, but it is restricted to D-nucleotides at the donor site
645162
Homo sapiens
?
-
-
-
-
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
10
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C
Dictyostelium sp.
14
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
22
-
dCMP
pH 7.4, 37°C
Dictyostelium sp.
30
-
dCMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
36
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
45
-
ara-CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
72
-
CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
73
-
dCMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
92
-
UMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
130
-
CMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
130
-
UMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
150
-
ara-CMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
217
-
UMP
pH 7.4, 37°C
Dictyostelium sp.
410
-
CMP
pH 7.4, 37°C
Dictyostelium sp.
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.12
-
CMP
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
0.5
-
CMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.5
-
UMP
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
1.5
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of His-tagged UMP-CMP kinase and UMP-CMP kinase fusion protein with glutathione S-transferase
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
CMP
substrate inhibition above 0.2 mM
Homo sapiens
UMP
substrate inhibition above 0.2 mM
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.12
-
CMP
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
0.5
-
CMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.5
-
UMP
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
1.5
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.022
-
CMP
pH 7.4, 37°C
Homo sapiens
0.044
-
UMP
pH 7.4, 37°C
Homo sapiens
0.045
-
UMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.07
-
CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.14
-
UMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.15
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.2
-
CMP
pH 7.4, 37°C
Dictyostelium sp.
0.2
-
UMP
pH 7.4, 37°C
Dictyostelium sp.
0.26
-
ara-CMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
0.3
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.34
-
ara-CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
0.9
-
dCMP
pH 7.4, 37°C, His-tagged UMP/CMP kinase
Homo sapiens
1.1
-
dCMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
2
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C
Dictyostelium sp.
2
-
cCMP
pH 7.4, 37°C
Dictyostelium sp.
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + CMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + CDP
-
-
?
ATP + dCMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + dCDP
-
-
?
ATP + UMP
Homo sapiens
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
ADP + UDP
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ara-CMP
-
645162
Homo sapiens
ADP + ara-CDP
-
-
-
?
ATP + ara-CMP
-
645162
Dictyostelium sp.
ADP + ara-CDP
-
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
645162
Homo sapiens
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine diphosphate
-
-
-
?
ATP + CMP
-
645162
Homo sapiens
ADP + CDP
-
-
-
?
ATP + CMP
-
645162
Dictyostelium sp.
ADP + CDP
-
-
-
?
ATP + CMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + CDP
-
-
-
?
ATP + dCMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + dCDP
-
-
-
?
ATP + L-(-)-2',3'-dideoxy-3'-thia-CMP
-
645162
Dictyostelium sp.
ADP + L-(-)-2',3'-dideoxy-3'-thia-CDP
-
-
-
-
ATP + UMP
-
645162
Homo sapiens
ADP + UDP
-
-
-
?
ATP + UMP
-
645162
Dictyostelium sp.
ADP + UDP
-
-
-
-
ATP + UMP
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
645162
Homo sapiens
ADP + UDP
-
-
-
?
additional information
the UMP-CMP kinase has a relaxed enantiospecificity for the nucleoside monophosphate acceptor site, but it is restricted to D-nucleotides at the donor site
645162
Homo sapiens
?
-
-
-
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
10
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C
Dictyostelium sp.
14
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, GST fusion UMP/CMP kinase
Homo sapiens
22
-
dCMP
pH 7.4, 37°C
Dictyostelium sp.
30
-
dCMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
36
-
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
45
-
ara-CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
72
-
CMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
73
-
dCMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
92
-
UMP
pH 7.4, 37°C, GST fusion UMP-CMP kinase
Homo sapiens
130
-
CMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
130
-
UMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
150
-
ara-CMP
pH 7.4, 37°C, His-tagged UMP-CMP kinase
Homo sapiens
217
-
UMP
pH 7.4, 37°C
Dictyostelium sp.
410
-
CMP
pH 7.4, 37°C
Dictyostelium sp.
Other publictions for EC 2.7.4.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739215
Topalis
Resistance to the nucleotide a ...
Homo sapiens
Oncotarget
7
10386-10401
2016
-
-
1
-
3
-
-
11
1
1
-
9
-
3
-
-
-
-
-
3
-
-
18
-
-
-
1
11
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
11
1
1
-
9
-
-
-
-
-
3
-
-
18
-
-
-
1
11
-
-
-
-
-
4
4
-
11
11
739700
Liu
Prognostic significance of nuc ...
Homo sapiens
Sci. Rep.
6
32027
2016
-
1
1
-
-
-
-
-
2
1
1
2
-
2
-
-
-
-
-
3
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
2
1
1
2
-
-
-
-
-
3
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
737991
Tsao
The contribution of CMP kinase ...
Homo sapiens
Cell Cycle
14
354-363
2015
-
-
-
-
1
-
-
-
1
1
-
2
-
1
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
702166
Liou
Modulation of human UMP/CMP ki ...
Homo sapiens
Biochem. Pharmacol.
79
381-388
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692040
Kocabas
Gemcitabine pharmacogenomics: ...
Homo sapiens
Drug Metab. Dispos.
36
1951-1959
2008
-
-
1
-
1
-
-
3
-
1
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693063
Xu
Human UMP-CMP kinase 2, a nove ...
Homo sapiens
J. Biol. Chem.
283
1563-1571
2008
-
-
1
-
2
-
-
4
2
1
-
1
-
2
-
-
1
-
-
6
-
-
5
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
4
2
1
-
1
-
-
-
1
-
6
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
693656
Lorenz
The influence of proline isome ...
Dictyostelium discoideum
J. Mol. Biol.
381
443-455
2008
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673598
Topalis
Nucleotide binding to human UM ...
Homo sapiens
FEBS J.
274
3704-3714
2007
-
1
1
1
-
-
6
5
-
1
-
-
-
2
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
4
-
6
-
1
1
-
1
-
-
6
6
4
5
-
1
-
-
-
-
-
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ATP:UMP-CMP phosphotransferase ...
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