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Literature summary for 2.7.4.1 extracted from

  • Chen, J.; Su, L.; Wang, X.; Zhang, T.; Liu, F.; Chen, H.; Tan, C.
    Polyphosphate kinase mediates antibiotic tolerance in extraintestinal pathogenic Escherichia coli PCN033 (2016), Front. Microbiol., 7, 724.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development the enzyme might be a potential drug target in bacteria Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
gene ppk Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information generation of a ppk knockout mutant strain, DELTAppk Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information MIC values of wild-type and mutant strain ExPEC for diverse antibiotics, i.e. beta-lactams cefotaxime, ceftazidime, ampicillin, cefazolin, tazobactam, and ticarcillin, glycopeptide vancomycin, aminoglycosides gentamicin, gentamicin sulfate, amikacin macrolide, erythromycin, quinolones norfloxacin and levofloxacin, sulfonamide trimethoprim, sulfadiazine nitrofurans macrodantin, and lipopeptde polymyxin B, overview. Biofilm-grown DELTAppk and wild-type cells are similarly tolerant and more tolerant than planktonic cells Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
an extraintestinal pathogenic Escherichia coli strain ExPEC, gene ppk
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Escherichia coli PCN033
-
an extraintestinal pathogenic Escherichia coli strain ExPEC, gene ppk
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information planktonic cells and cells in a biofilm Escherichia coli
-

Synonyms

Synonyms Comment Organism
PPK
-
Escherichia coli

General Information

General Information Comment Organism
malfunction planktonic cells of a ppk knockout strain (DELTAppk) are more susceptible to antibiotics than the wild-type strain, while biofilm-grown DELTAppk cells show similar susceptibility compared to the wild-type and are more tolerant than the planktonic cells. Phenotypes, overview Escherichia coli
physiological function enzyme PPK is important for the antibiotic stress response during the planktonic growth of extraintestinal pathogenic Escherichia coli Escherichia coli