Application | Comment | Organism |
---|---|---|
drug development | the enzyme might be a potential drug target in bacteria | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
gene ppk | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a ppk knockout mutant strain, DELTAppk | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | MIC values of wild-type and mutant strain ExPEC for diverse antibiotics, i.e. beta-lactams cefotaxime, ceftazidime, ampicillin, cefazolin, tazobactam, and ticarcillin, glycopeptide vancomycin, aminoglycosides gentamicin, gentamicin sulfate, amikacin macrolide, erythromycin, quinolones norfloxacin and levofloxacin, sulfonamide trimethoprim, sulfadiazine nitrofurans macrodantin, and lipopeptde polymyxin B, overview. Biofilm-grown DELTAppk and wild-type cells are similarly tolerant and more tolerant than planktonic cells | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
an extraintestinal pathogenic Escherichia coli strain ExPEC, gene ppk | - |
Escherichia coli PCN033 | - |
an extraintestinal pathogenic Escherichia coli strain ExPEC, gene ppk | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | planktonic cells and cells in a biofilm | Escherichia coli | - |
Synonyms | Comment | Organism |
---|---|---|
PPK | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | planktonic cells of a ppk knockout strain (DELTAppk) are more susceptible to antibiotics than the wild-type strain, while biofilm-grown DELTAppk cells show similar susceptibility compared to the wild-type and are more tolerant than the planktonic cells. Phenotypes, overview | Escherichia coli |
physiological function | enzyme PPK is important for the antibiotic stress response during the planktonic growth of extraintestinal pathogenic Escherichia coli | Escherichia coli |