Any feedback?
Literature summary for 2.7.4.1 extracted from
- The long and short of it - polyphosphate, PPK and bacterial survival (2008), Trends Biochem. Sci., 33, 284-290.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PPK1 exhibits potential as a target for chemotherapy | Klebsiella aerogenes |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Pseudomonas aeruginosa |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Dictyostelium discoideum |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Neisseria meningitidis |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Bacillus cereus |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Myxococcus xanthus |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Helicobacter pylori |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Bacillus anthracis |
| medicine | PPK1 exhibits potential as a target for chemotherapy | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
| Bacillus cereus | - |
- |
- |
| Dictyostelium discoideum | - |
- |
- |
| Escherichia coli | P0A7B1 | - |
- |
| Helicobacter pylori | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Myxococcus xanthus | - |
- |
- |
| Neisseria meningitidis | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (phosphate)n | - |
Klebsiella aerogenes | ADP + (phosphate)n+1 | - |
? |  |
| ATP + (phosphate)n | - |
Pseudomonas aeruginosa | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Dictyostelium discoideum | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Neisseria meningitidis | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Bacillus cereus | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Myxococcus xanthus | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Helicobacter pylori | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Bacillus anthracis | ADP + (phosphate)n+1 | - |
? | |
| ATP + (phosphate)n | - |
Escherichia coli | ADP + (phosphate)n+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| poly P kinase 1 | - |
Klebsiella aerogenes |
| poly P kinase 1 | - |
Pseudomonas aeruginosa |
| poly P kinase 1 | - |
Dictyostelium discoideum |
| poly P kinase 1 | - |
Neisseria meningitidis |
| poly P kinase 1 | - |
Bacillus cereus |
| poly P kinase 1 | - |
Myxococcus xanthus |
| poly P kinase 1 | - |
Helicobacter pylori |
| poly P kinase 1 | - |
Bacillus anthracis |
| poly P kinase 1 | - |
Escherichia coli |
| PPK1 | - |
Klebsiella aerogenes |
| PPK1 | - |
Pseudomonas aeruginosa |
| PPK1 | - |
Dictyostelium discoideum |
| PPK1 | - |
Neisseria meningitidis |
| PPK1 | - |
Bacillus cereus |
| PPK1 | - |
Myxococcus xanthus |
| PPK1 | - |
Helicobacter pylori |
| PPK1 | - |
Bacillus anthracis |
| PPK1 | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Klebsiella aerogenes | |
| ATP | - |
Pseudomonas aeruginosa | |
| ATP | - |
Dictyostelium discoideum | |
| ATP | - |
Neisseria meningitidis | |
| ATP | - |
Bacillus cereus | |
| ATP | - |
Myxococcus xanthus | |
| ATP | - |
Helicobacter pylori | |
| ATP | - |
Bacillus anthracis | |
| ATP | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deletion of ppk1 causes loss of virulence for animals | Klebsiella aerogenes |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Pseudomonas aeruginosa |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Dictyostelium discoideum |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Neisseria meningitidis |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Bacillus cereus |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Myxococcus xanthus |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Helicobacter pylori |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Bacillus anthracis |
| malfunction | deletion of ppk1 causes loss of virulence for animals | Escherichia coli |
| physiological function | PPK1 regulates error-prone DNA replication by DNA polymerase IV, leading to adaptive mutation | Escherichia coli |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
