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Literature summary for 2.7.3.9 extracted from

  • Gaigalat, L.; Schlueter, J.P.; Hartmann, M.; Mormann, S.; Tauch, A.; Puehler, A.; Kalinowski, J.
    The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum (2007), BMC Mol. Biol., 8, 104.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene ptsI encoding the enzyme, DNA and amino acid sequence determination and analysis, transcriptional organization and expression analysis, the genes encoding PTS components, namely ptsI, ptsH, and ptsF belong to the fructose-PTS gene cluster, whereas ptsG and ptsS are located in two separate regions. A gene coding for the DeoR-type transcriptional regulator sugR is involved in the transcriptional regulation of the fructose-PTS cluster genes of the C. glutamicum genome, overview. Organization of the intergenic region between the genes ptsI and cg2118 containing the binding motifs A and B Corynebacterium glutamicum
gene ptsI encoding the enzyme, DNA and amino acid sequence determination and analysis, transcriptional organization and expression analysis, the genes encoding PTS components, namely ptsI, ptsH, and ptsF belong to the fructose-PTS gene cluster, whereas ptsG and ptsS are located in two separate regions. A gene coding for the DeoR-type transcriptional regulator sugR is involved in the transcriptional regulation of the fructose-PTS cluster genes of the Corynebacterium glutamicum genome, overview. Organization of the intergenic region between the genes ptsI and cg2118 containing the binding motifs A and B Corynebacterium glutamicum

Protein Variants

Protein Variants Comment Organism
additional information replacement of HPr and EI of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the EIIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview Corynebacterium glutamicum
additional information replacement of HPr and enzyme I of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the enzyme IIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview Corynebacterium glutamicum

Inhibitors

Inhibitors Comment Organism Structure
additional information DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system, PTS, overview. Identification of the SugR binding motifs in ptsI by competitve EMSA studies, overview. The effectors fructose-1-phosphate, fructose-1,6-bisphosphate, and glucose-6-phosphate influence the binding activity of the SugR repressor Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + protein histidine Corynebacterium glutamicum the enzyme belongs to the phosphoenolpyruvate:sugar phosphotransferase system, PTS, which is the major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032, overview pyruvate + protein phospho-L-histidine
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Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum Q8NP83 strain ATCC 13032, gene ptsI
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + protein histidine
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Corynebacterium glutamicum pyruvate + protein phospho-L-histidine
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phosphoenolpyruvate + protein histidine the enzyme belongs to the phosphoenolpyruvate:sugar phosphotransferase system, PTS, which is the major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032, overview Corynebacterium glutamicum pyruvate + protein phospho-L-histidine
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?

Synonyms

Synonyms Comment Organism
More enzyme II is part of the bacterial phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli Corynebacterium glutamicum
phosphoenolpyruvate:sugar phosphotransferase system
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Corynebacterium glutamicum
phosphotransferase system enzyme I
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Corynebacterium glutamicum
PTS
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Corynebacterium glutamicum