Cloned (Comment) | Organism |
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gene ptsI encoding the enzyme, DNA and amino acid sequence determination and analysis, transcriptional organization and expression analysis, the genes encoding PTS components, namely ptsI, ptsH, and ptsF belong to the fructose-PTS gene cluster, whereas ptsG and ptsS are located in two separate regions. A gene coding for the DeoR-type transcriptional regulator sugR is involved in the transcriptional regulation of the fructose-PTS cluster genes of the C. glutamicum genome, overview. Organization of the intergenic region between the genes ptsI and cg2118 containing the binding motifs A and B | Corynebacterium glutamicum |
gene ptsI encoding the enzyme, DNA and amino acid sequence determination and analysis, transcriptional organization and expression analysis, the genes encoding PTS components, namely ptsI, ptsH, and ptsF belong to the fructose-PTS gene cluster, whereas ptsG and ptsS are located in two separate regions. A gene coding for the DeoR-type transcriptional regulator sugR is involved in the transcriptional regulation of the fructose-PTS cluster genes of the Corynebacterium glutamicum genome, overview. Organization of the intergenic region between the genes ptsI and cg2118 containing the binding motifs A and B | Corynebacterium glutamicum |
Protein Variants | Comment | Organism |
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additional information | replacement of HPr and EI of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the EIIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview | Corynebacterium glutamicum |
additional information | replacement of HPr and enzyme I of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the enzyme IIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview | Corynebacterium glutamicum |
Inhibitors | Comment | Organism | Structure |
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additional information | DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system, PTS, overview. Identification of the SugR binding motifs in ptsI by competitve EMSA studies, overview. The effectors fructose-1-phosphate, fructose-1,6-bisphosphate, and glucose-6-phosphate influence the binding activity of the SugR repressor | Corynebacterium glutamicum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
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phosphoenolpyruvate + protein histidine | Corynebacterium glutamicum | the enzyme belongs to the phosphoenolpyruvate:sugar phosphotransferase system, PTS, which is the major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032, overview | pyruvate + protein phospho-L-histidine | - |
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Organism | UniProt | Comment | Textmining |
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Corynebacterium glutamicum | Q8NP83 | strain ATCC 13032, gene ptsI | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + protein histidine | - |
Corynebacterium glutamicum | pyruvate + protein phospho-L-histidine | - |
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phosphoenolpyruvate + protein histidine | the enzyme belongs to the phosphoenolpyruvate:sugar phosphotransferase system, PTS, which is the major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032, overview | Corynebacterium glutamicum | pyruvate + protein phospho-L-histidine | - |
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Synonyms | Comment | Organism |
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More | enzyme II is part of the bacterial phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli | Corynebacterium glutamicum |
phosphoenolpyruvate:sugar phosphotransferase system | - |
Corynebacterium glutamicum |
phosphotransferase system enzyme I | - |
Corynebacterium glutamicum |
PTS | - |
Corynebacterium glutamicum |