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Literature summary for 2.7.3.2 extracted from

  • Grings, M.; Parmeggiani, B.; Moura, A.P.; de Moura Alvorcem, L.; Wyse, A.T.S.; Wajner, M.; Leipnitz, G.
    Evidence that thiosulfate inhibits creatine kinase activity in rat striatum via thiol group oxidation (2018), Neurotox. Res., 34, 693-705 .
    View publication on PubMed
Search for more literature for 2.7.3.2

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxymercuribenzoic acid
-
 Rattus norvegicus
thiosulfate 0.5 mM thiosulfate administration decreases the enzyme activity 30 min after administration. Thiosulfate also decreases the activity of the enzyme in vitro in striatum of rats, which is prevented by the thiol reducing agents dithiothreitol, the antioxidants glutathione, melatonin, trolox, and lipoic acid; thiosulfate (1 M) inhibits creatine kinase activity in rat striatum via thiol group oxidation is prevented by the thiol reducing agents dithiothreitol GSH, melatonin, trolox and lipoic acid Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphocreatine Rattus norvegicus
-
 ATP + creatine
-
 r
ATP + creatine Rattus norvegicus
-
 ADP + phosphocreatine
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphocreatine
-
 Rattus norvegicus ATP + creatine
-
 r
ATP + creatine
-
 Rattus norvegicus ADP + phosphocreatine
-
 r

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus