Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | organotellurium inhibits creatine kinase activity by two different mechanisms: competition with ADP and oxidation of critical sulfhydryl groups for the functioning of the enzyme | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.61 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
0.67 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
0.7 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
0.87 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.11 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
1.15 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
1.32 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.34 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.37 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.38 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.41 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.72 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
1.73 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.75 | - |
ATP | no organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
1.94 | - |
ATP | 0.005 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.03 | - |
ATP | 0.020 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.04 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.1 | - |
ATP | 0.005 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.1 | - |
ATP | no organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.49 | - |
ATP | 0.020 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.82 | - |
ATP | no organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.84 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.15 | - |
ATP | no organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.19 | - |
ATP | no organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
3.26 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.34 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.54 | - |
phosphocreatine | no organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.55 | - |
ATP | no organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
3.92 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
5.3 | 6 | ATP | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
5.77 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
6.43 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
6.68 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
8.97 | - |
phosphocreatine | no organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
17.52 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
20 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphocreatine | - |
Rattus norvegicus | ATP + creatine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
creatine kinase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.37 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.53 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
5.02 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
5.46 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
5.67 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
5.78 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
6.49 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
7.1 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
7.18 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
7.5 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
7.56 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
8 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
8.12 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
8.2 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
8.22 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
8.69 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
8.76 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
9.65 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
10.25 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
10.55 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
15.45 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
16 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
16.15 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
16.46 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus |