Literature summary for 2.7.3.2 extracted from

Pacheco, G.S.; Panatto, J.P.; Fagundes, D.A.; Scaini, G.; Bassani, C.; Jeremias, I.C.; Rezin, G.T.; Constantino, L.; Dal-Pizzol, F.; Streck, E.L.
Brain creatine kinase activity is inhibited after hepatic failure induced by carbon tetrachloride or acetaminophen (2009), Metab. Brain Dis., 24, 383-394.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetaminophen	inhibits creatine kinase in cerebellum and hippocampus, the administration of N-acetylcysteine plus deferoxamine reverses the inhibition of creatine kinase activity	Rattus norvegicus
carbon tetrachloride	inhibits creatine kinase activity in cerebellum, the administration of N-acetylcysteine plus deferoxamine reverses the inhibition of creatine kinase activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebellum	-	Rattus norvegicus	-
cerebral cortex	-	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-
prefrontal cortex	-	Rattus norvegicus	-
striatum	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + creatine	-	Rattus norvegicus	ADP + creatine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
brain creatine kinase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)