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Literature summary for 2.7.3.2 extracted from

  • Rech, V.C.; Feksa, L.R.; Fleck, R.M.; Athaydes, G.A.; Dornelles, P.K.; Rodrigues-Junior, V.; Wannmacher, C.M.
    Cysteamine prevents inhibition of thiol-containing enzymes caused by cystine or cystine dimethylester loading in rat brain cortex (2008), Metab. Brain Dis., 23, 133-145.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cystine inhibits creatine kinase activity possibly by oxidation of the sulfhydryl groups of the enzyme. Considering that creatine kinase like other thiol-containing enzymes, is crucial for energy homeostasis and antioxidant defenses, the enzymes inhibition caused by cystine released from lysosomes could be one of the mechanisms of tissue damage in patients with cystinosis Rattus norvegicus
cystine dimethylester
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar
-
Rattus norvegicus Wistar
-
Wistar
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphocreatine
-
Rattus norvegicus ATP + creatine
-
?
ADP + phosphocreatine
-
Rattus norvegicus Wistar ATP + creatine
-
?