Protein Variants | Comment | Organism |
---|---|---|
L115D | gradual decrease in enzyme activity and secondary structures, mutation does not affect enzyme inactivation by heat or guanidine hydrochloride. Inactivated mutant cannot recover activity by dilution-initiated refolding | Oryctolagus cuniculus |
L121D | gradual decrease in enzyme activity and secondary structures, mutation does not affect enzyme inactivation by heat or guanidine hydrochloride. Inactivated mutant cannot recover activity by dilution-initiated refolding | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.27 | - |
ATP | mutant L115D | Oryctolagus cuniculus | |
0.33 | - |
ATP | mutant L110D | Oryctolagus cuniculus | |
0.35 | - |
ATP | mutant L121D | Oryctolagus cuniculus | |
0.41 | - |
ATP | wild-type | Oryctolagus cuniculus | |
2.8 | - |
Creatine | mutant L110D | Oryctolagus cuniculus | |
3.1 | - |
Creatine | mutant L115D | Oryctolagus cuniculus | |
3.6 | - |
Creatine | mutant L121D | Oryctolagus cuniculus | |
8.7 | - |
Creatine | wild-type | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P00563 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
46.5 | - |
mutant L115D | Oryctolagus cuniculus |
94.4 | - |
mutant L121D | Oryctolagus cuniculus |
276 | - |
wild-type | Oryctolagus cuniculus |
299 | - |
mutant L110D | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + creatine | - |
Oryctolagus cuniculus | ADP + creatine phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | mutants L110D, L115D, L121D are faster on SDS-PAGE than wild-type protein | Oryctolagus cuniculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
51.9 | - |
melting temperature of mutant L110D | Oryctolagus cuniculus |
52.3 | - |
melting temperature of wild-type | Oryctolagus cuniculus |
52.9 | - |
melting temperature of mutant L121D | Oryctolagus cuniculus |
53.6 | - |
melting temperature of mutant L115D | Oryctolagus cuniculus |