Activating Compound | Comment | Organism | Structure |
---|---|---|---|
aripiprazole | activation of enzyme in striatum and cerebral cortex after chronic administration at 10 or 20 mg/kg. No effect on enzyme in hippocampus, cerebellum and prefrontal cortex | Rattus norvegicus | |
olanzapine | activation of enzyme in striatum after chronic administration at 10 mg/kg | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | study on the effect of antipsychotics haloperidol, clozapine, olanzapine or aripiprazole chronic administration on creatine kinase in rat brain | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clozapine | inhibition of enzyme in cerebellum and prefrontal cortex after chronic administration | Rattus norvegicus | |
additional information | haloperidol, no effect on enzyme. Aripiprazole, no effect on enzyme in hippocampus, cerebellum and prefrontal cortex | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |