BRENDA - Enzyme Database
show all sequences of 2.7.3.2

Relating structure to mechanism in creatine kinase

McLeish, M.; Kenyon, G.; Crit. Rev. Biochem. Mol. Biol. 40, 1-20 (2005)

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
enzyme is clinically important as an indicator of myocardial and skeletal muscle disorders and for the diagnosis of acute myocardial infarction
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expression of soluble monomeric or dimeric mutants
Oryctolagus cuniculus
Crystallization (Commentary)
Crystallization
Organism
crystal structure analysis of muscle cytosolic isozyme
Bos taurus
crystal structure analysis of muscle cytosolic isozyme
Oryctolagus cuniculus
crystal structure analysis of muscle-type cytosolic isozyme crystallized with transition state analogue complex
Tetronarce californica
crystal structure analysis of muscle-type cytosolic isozyme, and of ubiquitous mitochondrial isozyme, and of cytosolic brain type isozyme
Homo sapiens
crystal structure analysis of the cytosolic brain isozyme, and of the cardiac sarcomeric mitochondrial crystallized free or bound to MgATP or transition state analogue complex
Gallus gallus
Inhibitors
Inhibitors
Commentary
Organism
Structure
formate
mimics the phosphoryl group in the transition state
Bos taurus
formate
mimics the phosphoryl group in the transition state
Gallus gallus
formate
mimics the phosphoryl group in the transition state
Homo sapiens
formate
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
formate
mimics the phosphoryl group in the transition state
Tetronarce californica
guanidinium hydrochloride
first dissociation of subunits, then unfolding into random coil
Oryctolagus cuniculus
iodoacetamide
substrates can protect against alkylation
Bos taurus
iodoacetamide
substrates can protect against alkylation
Gallus gallus
iodoacetamide
substrates can protect against alkylation
Homo sapiens
iodoacetamide
substrates can protect against alkylation
Oryctolagus cuniculus
iodoacetamide
substrates can protect against alkylation
Tetronarce californica
nitrate
mimics the phosphoryl group in the transition state
Bos taurus
nitrate
mimics the phosphoryl group in the transition state
Gallus gallus
nitrate
mimics the phosphoryl group in the transition state
Homo sapiens
nitrate
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
nitrate
mimics the phosphoryl group in the transition state
Tetronarce californica
nitrite
mimics the phosphoryl group in the transition state
Bos taurus
nitrite
mimics the phosphoryl group in the transition state
Gallus gallus
nitrite
mimics the phosphoryl group in the transition state
Homo sapiens
nitrite
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
nitrite
mimics the phosphoryl group in the transition state
Tetronarce californica
Phenylglyoxal
complete inactivation, reacts on arginine residues
Oryctolagus cuniculus
phosphate
competitive against ATP and phosphocreatine, noncompetitive against ADP and creatine
Homo sapiens
SDS
dissociation of subunits, no unfolding
Oryctolagus cuniculus
sulfate
competitive against ATP and phosphocreatine, noncompetitive against ADP and creatine
Homo sapiens
transition state analogue complex
consists of creatine, MgADP, and planar ions such as nitrate, nitrite, and formate, binding structure
Homo sapiens
transition state analogue complex
creatine, MgADP-, and planar ions such as nitrate, nitrite, and formate
Tetronarce californica
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Bos taurus
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Gallus gallus
additional information
-
additional information
kinetic mechanism, the enzyme shows negative cooperativity and nonidentical active sites
Homo sapiens
additional information
-
additional information
kinetic mechanism, the enzyme shows negative cooperativity and nonidentical active sites
Oryctolagus cuniculus
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Tetronarce californica
0.03
-
ADP
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
0.04
-
ADP
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
0.11
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.13
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.15
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.51
-
phosphocreatine
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
0.55
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.68
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.81
-
ATP
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
0.89
-
ATP
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
1.01
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
1.16
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
1.33
-
phosphocreatine
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
4.9
-
Creatine
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
7.31
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
9.5
-
Creatine
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Tetronarce californica
5829
-
cytosol
-
Gallus gallus
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
mitochondrion
-
Bos taurus
5739
-
mitochondrion
-
Oryctolagus cuniculus
5739
-
mitochondrion
-
Tetronarce californica
5739
-
mitochondrion
-
Gallus gallus
5739
-
mitochondrion
-
Homo sapiens
5739
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Mg2+
-
Gallus gallus
Mg2+
binding structure
Homo sapiens
Mg2+
binding structure
Oryctolagus cuniculus
Mg2+
binding structure
Tetronarce californica
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
78500
85100
cytosolic muscle isozyme
Bos taurus
78500
85100
cytosolic muscle isozyme
Gallus gallus
78500
85100
cytosolic muscle isozyme
Homo sapiens
82600
-
cytosolic muscle isozyme, gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + creatine
Gallus gallus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Homo sapiens
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Bos taurus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Oryctolagus cuniculus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Tetronarce californica
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
additional information
Gallus gallus
probable enzyme evolution, overview
?
-
-
-
additional information
Homo sapiens
probable enzyme evolution, overview
?
-
-
-
additional information
Bos taurus
probable enzyme evolution, overview
?
-
-
-
additional information
Oryctolagus cuniculus
probable enzyme evolution, overview
?
-
-
-
additional information
Tetronarce californica
probable enzyme evolution, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
4 isozymes encoded by 4 different genes: 2 cytosolic isozymes, a muscle-type MM-CK and a brain-type BB-CK or a heterodimer MB-CK, and 2 mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK
-
Gallus gallus
P11009
4 isozymes encoded by 4 different genes: 2 cytosolic isozymes, a muscle-type MM-CK and a brain-type BB-CK or a heterodimer MB-CK, and 2 mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK
-
Homo sapiens
-
4 isozymes encoded by 4 different genes: 2 cytosolic isozymes, a muscle-type MM-CK and a brain-type BB-CK or a heterodimer MB-CK, and 2 mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK
-
Oryctolagus cuniculus
-
4 isozymes encoded by 4 different genes: 2 cytosolic isozymes, a muscle-type MM-CK and a brain-type BB-CK or a heterodimer MB-CK, and 2 mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK
-
Tetronarce californica
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant soluble monomeric or dimeric mutant enzymes by affinity chromatography, native enzyme from skeletal muscle, at high ionic strength, low temperature, and by fractionation with ethanol, or by affinity and ion exchange chromatography
Oryctolagus cuniculus
Reaction
Reaction
Commentary
Organism
ATP + creatine = ADP + phosphocreatine
catalytic cysteine, the enzyme follows a random or an ordered bimolecular mechanism dependent on pH, direct phosphoryl transfer, no phosphorylated intermediate, overview
Bos taurus
ATP + creatine = ADP + phosphocreatine
catalytic cysteine, active site residues are Glu226, Glu227, and Asp228, the enzyme follows a random or an ordered bimolecular mechanism dependent on pH, direct phosphoryl transfer, no phosphorylated intermediate, overview
Gallus gallus
ATP + creatine = ADP + phosphocreatine
catalytic cysteine, the enzyme follows a random or an ordered bimolecular mechanism dependent on pH, direct phosphoryl transfer, no phosphorylated intermediate, overview
Homo sapiens
ATP + creatine = ADP + phosphocreatine
catalytic cysteine, the enzyme follows a random or an ordered bimolecular mechanism dependent on pH, direct phosphoryl transfer, no phosphorylated intermediate, overview
Oryctolagus cuniculus
ATP + creatine = ADP + phosphocreatine
catalytic cysteine, active site structure involving His66 and Asp326, overview, the enzyme follows a random or an ordered bimolecular mechanism dependent on pH, direct phosphoryl transfer, no phosphorylated intermediate, overview
Tetronarce californica
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Gallus gallus
-
heart
-
Gallus gallus
-
skeletal muscle
-
Bos taurus
-
skeletal muscle
-
Oryctolagus cuniculus
-
skeletal muscle
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + creatine
-
661528
Gallus gallus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Bos taurus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Oryctolagus cuniculus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Tetronarce californica
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Gallus gallus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Homo sapiens
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Bos taurus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Oryctolagus cuniculus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Tetronarce californica
ADP + phosphocreatine
-
-
-
r
ATP + creatine
the reaction equilibrium lies towards ATP production
661528
Homo sapiens
ADP + phosphocreatine
-
-
-
r
ATP + cyclocreatine
i.e. 1-carboxymethy-2-iminoimidazolidine
661528
Oryctolagus cuniculus
ADP + phospho-cyclocreatine
-
-
-
?
ATP + cyclocreatine
i.e. 1-carboxymethyl-2-iminoimidazolidine
661528
Homo sapiens
ADP + phospho-cyclocreatine
-
-
-
?
ATP + glycocyamine
very low activity
661528
Homo sapiens
ADP + glycocyamine phosphate
-
-
-
?
ATP + glycocyamine
very low activity
661528
Oryctolagus cuniculus
ADP + glycocyamine phosphate
-
-
-
?
ATP + N-ethylglycocyamine
-
661528
Homo sapiens
ADP + N-ethylglycocyamine phosphate
-
-
-
?
ATP + N-ethylglycocyamine
-
661528
Oryctolagus cuniculus
ADP + N-ethylglycocyamine phosphate
-
-
-
?
additional information
probable enzyme evolution, overview
661528
Gallus gallus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Homo sapiens
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Bos taurus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Oryctolagus cuniculus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Tetronarce californica
?
-
-
-
-
additional information
substrate binding structure, arginine residues R130, R132, R236, R292, and R320 form a nucleotide phosphate bindig pocket, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Homo sapiens
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, assay methods, overview, structure-function analysis, substrate specificity of isozymes, the cytosolic isozymes of skeletal muscle shows broad substrate specificity
661528
Oryctolagus cuniculus
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Gallus gallus
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Bos taurus
?
-
-
-
-
additional information
substrate binding structure, substrate binding at both subunits
661528
Tetronarce californica
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 40000-44000, mature enzyme
Tetronarce californica
dimer
2 * 40000-44000, mature cytosolic isozymes
Bos taurus
dimer
2 * 40000-44000, mature cytosolic isozymes
Gallus gallus
dimer
2 * 40000-44000, mature cytosolic isozymes
Homo sapiens
dimer
2 * 40000-44000, mature cytosolic isozymes
Oryctolagus cuniculus
More
analysis of the structure of cardiac sarcomeric mitochondrial isozyme, free or bound to MgATP or transition state analogue complex
Gallus gallus
More
structure-function analysis, the monomeric enzyme is active, the subunits act independently
Oryctolagus cuniculus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Bos taurus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Gallus gallus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Homo sapiens
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Oryctolagus cuniculus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
51.7
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
51.7
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
75
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
75
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
78.3
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
78.3
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
90
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
90
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
153.5
-
ATP
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
153.5
-
Creatine
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
215
-
ATP
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
215
-
Creatine
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
350
-
ADP
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
350
-
phosphocreatine
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
483.3
-
ADP
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
483.3
-
phosphocreatine
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
assay at
Homo sapiens
7
9
assay at
Oryctolagus cuniculus
Cofactor
Cofactor
Commentary
Organism
Structure
ADP
-
Bos taurus
ADP
-
Gallus gallus
ADP
binding structure
Tetronarce californica
ADP
-
Oryctolagus cuniculus
ADP
-
Homo sapiens
ATP
-
Bos taurus
ATP
-
Gallus gallus
ATP
binding structure
Tetronarce californica
ATP
-
Oryctolagus cuniculus
ATP
-
Homo sapiens
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Bos taurus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Gallus gallus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Homo sapiens
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Oryctolagus cuniculus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and are therefore also termed the acidic and basic isozymes
-
additional information
Application (protein specific)
Application
Commentary
Organism
diagnostics
enzyme is clinically important as an indicator of myocardial and skeletal muscle disorders and for the diagnosis of acute myocardial infarction
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of soluble monomeric or dimeric mutants
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ADP
-
Bos taurus
ADP
-
Gallus gallus
ADP
-
Homo sapiens
ADP
-
Oryctolagus cuniculus
ADP
binding structure
Tetronarce californica
ATP
-
Bos taurus
ATP
-
Gallus gallus
ATP
binding structure
Tetronarce californica
ATP
-
Homo sapiens
ATP
-
Oryctolagus cuniculus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
crystal structure analysis of muscle cytosolic isozyme
Bos taurus
crystal structure analysis of muscle cytosolic isozyme
Oryctolagus cuniculus
crystal structure analysis of muscle-type cytosolic isozyme crystallized with transition state analogue complex
Tetronarce californica
crystal structure analysis of muscle-type cytosolic isozyme, and of ubiquitous mitochondrial isozyme, and of cytosolic brain type isozyme
Homo sapiens
crystal structure analysis of the cytosolic brain isozyme, and of the cardiac sarcomeric mitochondrial crystallized free or bound to MgATP or transition state analogue complex
Gallus gallus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
formate
mimics the phosphoryl group in the transition state
Bos taurus
formate
mimics the phosphoryl group in the transition state
Gallus gallus
formate
mimics the phosphoryl group in the transition state
Homo sapiens
formate
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
formate
mimics the phosphoryl group in the transition state
Tetronarce californica
guanidinium hydrochloride
first dissociation of subunits, then unfolding into random coil
Oryctolagus cuniculus
iodoacetamide
substrates can protect against alkylation
Bos taurus
iodoacetamide
substrates can protect against alkylation
Gallus gallus
iodoacetamide
substrates can protect against alkylation
Homo sapiens
iodoacetamide
substrates can protect against alkylation
Oryctolagus cuniculus
iodoacetamide
substrates can protect against alkylation
Tetronarce californica
nitrate
mimics the phosphoryl group in the transition state
Bos taurus
nitrate
mimics the phosphoryl group in the transition state
Gallus gallus
nitrate
mimics the phosphoryl group in the transition state
Homo sapiens
nitrate
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
nitrate
mimics the phosphoryl group in the transition state
Tetronarce californica
nitrite
mimics the phosphoryl group in the transition state
Bos taurus
nitrite
mimics the phosphoryl group in the transition state
Gallus gallus
nitrite
mimics the phosphoryl group in the transition state
Homo sapiens
nitrite
mimics the phosphoryl group in the transition state
Oryctolagus cuniculus
nitrite
mimics the phosphoryl group in the transition state
Tetronarce californica
Phenylglyoxal
complete inactivation, reacts on arginine residues
Oryctolagus cuniculus
phosphate
competitive against ATP and phosphocreatine, noncompetitive against ADP and creatine
Homo sapiens
SDS
dissociation of subunits, no unfolding
Oryctolagus cuniculus
sulfate
competitive against ATP and phosphocreatine, noncompetitive against ADP and creatine
Homo sapiens
transition state analogue complex
consists of creatine, MgADP, and planar ions such as nitrate, nitrite, and formate, binding structure
Homo sapiens
transition state analogue complex
creatine, MgADP-, and planar ions such as nitrate, nitrite, and formate
Tetronarce californica
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Bos taurus
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Gallus gallus
additional information
-
additional information
kinetic mechanism, the enzyme shows negative cooperativity and nonidentical active sites
Homo sapiens
additional information
-
additional information
kinetic mechanism, the enzyme shows negative cooperativity and nonidentical active sites
Oryctolagus cuniculus
additional information
-
additional information
kinetics, the enzyme shows negative cooperativity and nonidentical active sites
Tetronarce californica
0.03
-
ADP
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
0.04
-
ADP
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
0.11
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.13
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.15
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.51
-
phosphocreatine
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
0.55
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.68
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
0.81
-
ATP
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
0.89
-
ATP
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
1.01
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
1.16
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
1.33
-
phosphocreatine
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
4.9
-
Creatine
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
7.31
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
9.5
-
Creatine
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Tetronarce californica
5829
-
cytosol
-
Gallus gallus
5829
-
mitochondrion
-
Bos taurus
5739
-
mitochondrion
-
Oryctolagus cuniculus
5739
-
mitochondrion
-
Tetronarce californica
5739
-
mitochondrion
-
Gallus gallus
5739
-
mitochondrion
-
Homo sapiens
5739
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Mg2+
-
Gallus gallus
Mg2+
binding structure
Homo sapiens
Mg2+
binding structure
Oryctolagus cuniculus
Mg2+
binding structure
Tetronarce californica
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
78500
85100
cytosolic muscle isozyme
Bos taurus
78500
85100
cytosolic muscle isozyme
Gallus gallus
78500
85100
cytosolic muscle isozyme
Homo sapiens
82600
-
cytosolic muscle isozyme, gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + creatine
Gallus gallus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Homo sapiens
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Bos taurus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Oryctolagus cuniculus
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
ATP + creatine
Tetronarce californica
key enzyme in energy homeostasis
ADP + phosphocreatine
-
-
r
additional information
Gallus gallus
probable enzyme evolution, overview
?
-
-
-
additional information
Homo sapiens
probable enzyme evolution, overview
?
-
-
-
additional information
Bos taurus
probable enzyme evolution, overview
?
-
-
-
additional information
Oryctolagus cuniculus
probable enzyme evolution, overview
?
-
-
-
additional information
Tetronarce californica
probable enzyme evolution, overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant soluble monomeric or dimeric mutant enzymes by affinity chromatography, native enzyme from skeletal muscle, at high ionic strength, low temperature, and by fractionation with ethanol, or by affinity and ion exchange chromatography
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Gallus gallus
-
heart
-
Gallus gallus
-
skeletal muscle
-
Bos taurus
-
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + creatine
-
661528
Gallus gallus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Bos taurus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Oryctolagus cuniculus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
-
661528
Tetronarce californica
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Gallus gallus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Homo sapiens
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Bos taurus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Oryctolagus cuniculus
ADP + phosphocreatine
-
-
-
r
ATP + creatine
key enzyme in energy homeostasis
661528
Tetronarce californica
ADP + phosphocreatine
-
-
-
r
ATP + creatine
the reaction equilibrium lies towards ATP production
661528
Homo sapiens
ADP + phosphocreatine
-
-
-
r
ATP + cyclocreatine
i.e. 1-carboxymethy-2-iminoimidazolidine
661528
Oryctolagus cuniculus
ADP + phospho-cyclocreatine
-
-
-
?
ATP + cyclocreatine
i.e. 1-carboxymethyl-2-iminoimidazolidine
661528
Homo sapiens
ADP + phospho-cyclocreatine
-
-
-
?
ATP + glycocyamine
very low activity
661528
Homo sapiens
ADP + glycocyamine phosphate
-
-
-
?
ATP + glycocyamine
very low activity
661528
Oryctolagus cuniculus
ADP + glycocyamine phosphate
-
-
-
?
ATP + N-ethylglycocyamine
-
661528
Homo sapiens
ADP + N-ethylglycocyamine phosphate
-
-
-
?
ATP + N-ethylglycocyamine
-
661528
Oryctolagus cuniculus
ADP + N-ethylglycocyamine phosphate
-
-
-
?
additional information
probable enzyme evolution, overview
661528
Gallus gallus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Homo sapiens
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Bos taurus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Oryctolagus cuniculus
?
-
-
-
-
additional information
probable enzyme evolution, overview
661528
Tetronarce californica
?
-
-
-
-
additional information
substrate binding structure, arginine residues R130, R132, R236, R292, and R320 form a nucleotide phosphate bindig pocket, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Homo sapiens
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, assay methods, overview, structure-function analysis, substrate specificity of isozymes, the cytosolic isozymes of skeletal muscle shows broad substrate specificity
661528
Oryctolagus cuniculus
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Gallus gallus
?
-
-
-
-
additional information
substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes
661528
Bos taurus
?
-
-
-
-
additional information
substrate binding structure, substrate binding at both subunits
661528
Tetronarce californica
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 40000-44000, mature enzyme
Tetronarce californica
dimer
2 * 40000-44000, mature cytosolic isozymes
Bos taurus
dimer
2 * 40000-44000, mature cytosolic isozymes
Gallus gallus
dimer
2 * 40000-44000, mature cytosolic isozymes
Homo sapiens
dimer
2 * 40000-44000, mature cytosolic isozymes
Oryctolagus cuniculus
More
analysis of the structure of cardiac sarcomeric mitochondrial isozyme, free or bound to MgATP or transition state analogue complex
Gallus gallus
More
structure-function analysis, the monomeric enzyme is active, the subunits act independently
Oryctolagus cuniculus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Bos taurus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Gallus gallus
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Homo sapiens
octamer
8 * 40000-44000, mature mitochondrial isozymes, can dissociate to dimers dependent on conditions
Oryctolagus cuniculus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
51.7
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
51.7
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
75
-
ATP
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
75
-
Creatine
pH 8.0, ubiquitous mitochondrial isozyme
Homo sapiens
78.3
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
78.3
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
90
-
ADP
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
90
-
phosphocreatine
pH 7.0, ubiquitous mitochondrial isozyme
Homo sapiens
153.5
-
ATP
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
153.5
-
Creatine
pH 9.0, muscle-type cytosolic isozyme
Homo sapiens
215
-
ATP
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
215
-
Creatine
pH 9.0, brain-type cytosolic isozyme
Homo sapiens
350
-
ADP
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
350
-
phosphocreatine
pH 7.0, brain-type cytosolic isozyme
Homo sapiens
483.3
-
ADP
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
483.3
-
phosphocreatine
pH 7.0, muscle-type cytosolic isozyme
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
assay at
Homo sapiens
7
9
assay at
Oryctolagus cuniculus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Bos taurus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Gallus gallus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Homo sapiens
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and ar therefore also termed the acidic and basic isozymes
-
additional information
Oryctolagus cuniculus
the mitochondrial isozymes, a ubiquitous MiU-CK and a sarcomeric MiS-CK differ in their pI and are therefore also termed the acidic and basic isozymes
-
additional information
Other publictions for EC 2.7.3.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737427
Schlattner
Cellular compartmentation of e ...
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Amino Acids
48
1751-1774
2016
-
-
1
-
1
-
-
-
18
2
-
7
-
4
-
2
1
-
-
11
-
-
8
3
1
-
-
-
1
-
-
4
-
-
-
-
-
1
6
-
1
-
-
-
-
-
21
3
-
7
-
-
2
1
-
14
-
-
8
4
1
-
-
-
1
-
-
-
-
7
11
-
-
-
738403
Cai
Effect of Cd2+ on muscle type ...
Pelodiscus sinensis
Int. J. Biol. Macromol.
83
233-241
2016
-
-
-
-
-
-
1
2
-
1
-
1
-
3
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
-
-
1
3
-
1
-
-
-
1
-
-
-
1
1
3
2
-
1
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
737719
Londergan
Dynamic asymmetry and the role ...
Oryctolagus cuniculus
Biochemistry
54
83-95
2015
-
-
-
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738079
Niedzwiecka
Purification and stability of ...
Clupea harengus
Comp. Biochem. Physiol. B
185
16-23
2015
-
-
-
-
-
-
1
-
1
1
2
2
-
4
-
-
1
-
-
1
1
-
2
3
1
1
2
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
2
-
-
2
2
4
2
-
-
-
2
-
2
2
-
2
6
2
2
4
-
-
-
-
-
-
1
2
-
-
-
739256
Wu
The activity of carp muscle-sp ...
Cyprinus carpio, Oryctolagus cuniculus
Physiol. Biochem. Zool.
87
507-516
2014
-
-
-
-
7
2
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
7
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
739653
Horjus
Creatine kinase inhibits ADP-i ...
Homo sapiens
Sci. Rep.
4
6551
2014
-
-
-
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721310
Fan
Inactivation of recombinant hu ...
Homo sapiens
Appl. Biochem. Biotechnol.
169
268-280
2013
-
-
1
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
737741
Lin
Enhancement of brain-type crea ...
Homo sapiens, Mus musculus, Mus musculus R6/2
Biochim. Biophys. Acta
1832
742-753
2013
-
1
1
-
-
-
-
-
1
2
-
3
-
6
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
1
1
4
-
-
-
-
-
-
-
1
2
-
3
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
1
4
4
1
-
-
739050
Boeck
Mitochondrial respiratory chai ...
Mus musculus, Mus musculus CF-1
Mol. Cell. Biochem.
384
129-137
2013
-
-
-
-
-
-
1
-
2
1
-
2
-
3
-
-
-
-
-
4
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
1
-
2
-
-
-
-
-
4
-
-
2
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
739598
Feng
Effects of the Fc-III tag on a ...
Homo sapiens
Protein Sci.
22
1008-1015
2013
-
-
1
-
1
-
1
-
-
1
-
1
-
2
-
-
1
-
-
2
-
-
1
1
1
-
1
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
1
-
-
-
1
-
1
-
-
-
1
-
2
-
-
1
1
1
-
1
-
1
-
-
-
-
1
1
-
-
-
721916
Arnold
High levels of brain-type crea ...
Homo sapiens
Blood Cells Mol. Dis.
48
62-67
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
722245
Riviere
Dynamical properties of the lo ...
Oryctolagus cuniculus
FEBS J.
279
2863-2875
2012
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722307
de Andrade
Kinetic studies on the inhibit ...
Rattus norvegicus
Food Chem. Toxicol.
50
3468-3474
2012
-
-
-
-
-
-
1
35
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
24
-
-
-
-
-
-
-
-
-
-
1
24
35
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721259
Jeneson
Similar mitochondrial activati ...
Mus musculus
Am. J. Physiol. Regul. Integr. Comp. Physiol.
300
1316-1325
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722077
Wu
Activity and function of rabbi ...
Oryctolagus cuniculus
Comp. Biochem. Physiol. B
158
189-198
2011
-
-
-
1
3
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701761
Mu
Kinetics of Zn2+-induced brain ...
Oryctolagus cuniculus
Appl. Biochem. Biotechnol.
160
1309-1320
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
1
2
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701768
Lue
Structural analysis and inhibi ...
Homo sapiens
Appl. Biochem. Biotechnol.
160
831-842
2010
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703504
Streijger
Complete brain-type creatine k ...
Mus musculus
Epilepsia
51
79-88
2010
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721956
Yerlykina
Enzymatic characteristics of c ...
Rattus norvegicus
Bull. Exp. Biol. Med.
149
14-17
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722398
Gao
Isoenzyme-specific thermostabi ...
Homo sapiens
Int. J. Biol. Macromol.
47
27-32
2010
-
-
1
-
-
-
-
6
1
-
2
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
5
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
1
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
5
3
-
-
-
-
-
-
-
-
-
-
722399
Gao
Dissecting the key residues cr ...
Danio rerio, Homo sapiens
Int. J. Biol. Macromol.
47
366-370
2010
-
-
2
-
18
-
-
38
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
-
1
1
2
19
-
-
-
-
-
-
-
-
-
2
-
-
18
-
-
-
-
38
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
1
2
19
-
-
-
-
-
-
-
-
-
-
722684
Yang
Regulation of sodium-calcium e ...
Homo sapiens
J. Biol. Chem.
285
28275-28285
2010
-
-
-
-
13
-
-
-
3
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703836
Tylkova
Architectural and functional r ...
Mus musculus
Gen. Physiol. Biophys.
28
219-224
2009
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704042
Li
COMMD6 from amphioxus Branchio ...
Oryctolagus cuniculus
Int. J. Biochem. Cell Biol.
41
2459-2465
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704051
Lue
The effects of acrylamide on b ...
Oryctolagus cuniculus
Int. J. Biol. Macromol.
44
128-132
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704082
Bourdelas
Dynamic expression pattern of ...
Xenopus laevis
Int. J. Dev. Biol.
53
1075-1079
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
705501
Tonin
Inhibition of creatine kinase ...
Rattus norvegicus
Metab. Brain Dis.
24
349-360
2009
-
-
-
-
-
-
1
-
2
-
-
-
-
5
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705502
Pacheco
Brain creatine kinase activity ...
Rattus norvegicus
Metab. Brain Dis.
24
383-394
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706831
Lepper
Lead inhibits in vitro creatin ...
Rattus norvegicus
Toxicol. In Vitro
24
1045-1051
2009
-
-
-
-
-
-
2
-
2
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684382
Bennett
Pharmacokinetic and pharmacody ...
Canis lupus familiaris
Am. J. Trop. Med. Hyg.
79
36-41
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685504
Wennefors
Stereospecificity, substrate, ...
Oryctolagus cuniculus
Bioorg. Chem.
36
169-177
2008
-
-
-
-
-
-
1
3
-
-
-
-
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
3
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
685679
Yu
Leptin promotes proliferation ...
Sus scrofa
Biosci. Biotechnol. Biochem.
72
13-21
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686183
Ren
Creatine kinase inhibitor iodo ...
Rattus norvegicus
Clin. Exp. Pharmacol. Physiol.
36
141-145
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687261
Xie
Inhibition of acrylamide toxic ...
Mus musculus
J. Agric. Food Chem.
56
6054-6060
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688203
Gruberg
Troponin-positive, CK-MB-negat ...
Homo sapiens
J. Invasive Cardiol.
20
125-128
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688324
Bong
Overexpression, purification, ...
Homo sapiens
J. Microbiol. Biotechnol.
18
295-298
2008
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688814
Rech
Cysteamine prevents inhibition ...
Rattus norvegicus, Rattus norvegicus Wistar
Metab. Brain Dis.
23
133-145
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
170
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689220
Di-Pietro
Inhibition of brain creatine k ...
Rattus norvegicus, Rattus norvegicus Wistar
Neurosci. Lett.
434
139-143
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
169
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689889
Iwanami
Cytoplasmic and mitochondrial ...
Physeter catodon
Protein J.
27
43-49
2008
-
-
1
-
-
-
-
4
2
-
-
-
-
6
-
-
-
-
-
1
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
697687
Vissing
Effects of concentric and repe ...
Homo sapiens
Eur. J. Appl. Physiol.
103
323-332
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702414
Wang
Detection of local polarity an ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1784
415-422
2008
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671058
Ohren
Structural asymmetry and inter ...
Oryctolagus cuniculus
Acta Crystallogr. Sect. D
63
381-389
2007
-
-
-
1
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671618
Awama
Despite its high similarity wi ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
458
158-166
2007
-
-
-
-
1
1
3
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671627
Abnous
Regulation of skeletal muscle ...
Urocitellus richardsonii
Arch. Biochem. Biophys.
467
10-19
2007
-
-
-
-
-
-
-
6
-
-
1
-
-
4
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671632
Pereira Oliveira
Cystine inhibits creatine kina ...
Sus scrofa
Arch. Med. Res.
38
164-169
2007
-
-
-
-
-
-
1
-
2
-
-
-
-
4
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671679
Assis
Effect of antipsychotics on cr ...
Rattus norvegicus
Basic Clin. Pharmacol. Toxicol.
101
315-319
2007
2
1
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673067
Eliuk
Active site modifications of t ...
Homo sapiens
Chem. Res. Toxicol.
20
1260-1268
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674027
He
Role of the linker between the ...
Oryctolagus cuniculus
Int. J. Biochem. Cell Biol.
39
1816-1827
2007
-
-
-
-
2
-
-
8
-
-
-
-
-
2
-
-
-
-
-
2
4
-
1
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
-
2
4
-
1
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
674031
Feng
Effects of the single point ge ...
Homo sapiens
Int. J. Biochem. Cell Biol.
39
392-401
2007
-
-
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
1
3
-
1
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
3
-
1
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
674788
Zhao
The generation of the oxidized ...
Oryctolagus cuniculus
J. Biol. Chem.
282
12022-12029
2007
-
-
1
-
4
-
-
6
-
-
-
-
-
1
-
1
-
-
-
1
3
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
6
-
-
-
-
-
-
1
-
-
1
3
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674947
Zou
Monomeric creatine kinase aggr ...
Oryctolagus cuniculus
J. Biomol. Struct. Dyn.
24
359-367
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675240
Zanette
Modulation of creatine kinase ...
Rattus norvegicus
J. Inorg. Biochem.
101
267-273
2007
2
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675316
Bretonnet
NMR screening applied to the f ...
Oryctolagus cuniculus
J. Med. Chem.
50
1865-1875
2007
-
-
-
1
-
-
7
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
7
2
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675783
Delwing
Arginine administration reduce ...
Rattus norvegicus
Metab. Brain Dis.
22
13-23
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675955
Buerklen
Brain-type creatine kinase BB- ...
Homo sapiens
Mol. Cell. Biochem.
297
53-64
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675956
Zurmanova
Creatine kinase binds more fir ...
Oryctolagus cuniculus
Mol. Cell. Biochem.
305
55-61
2007
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675957
Lenz
Inhibition of cytosolic and mi ...
Homo sapiens
Mol. Cell. Biochem.
306
153-162
2007
-
-
-
-
-
-
-
-
3
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676173
Shin
Hair bundles are specialized f ...
Gallus gallus, Mus musculus
Neuron
53
371-386
2007
-
-
-
-
1
-
-
-
1
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685344
Zugno
Evidence that the inhibitory e ...
Rattus norvegicus
Biochim. Biophys. Acta
1772
563-569
2007
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686860
Daosukho
Phenylbutyrate, a histone deac ...
Mus musculus
Free Radic. Biol. Med.
42
1818-1825
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687322
Berri
Consequence of muscle hypertro ...
Gallus gallus
J. Anim. Sci.
85
2005-2011
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689192
Illa
Symptomatic dysferlin gene mut ...
Homo sapiens
Neurology
68
1284-1289
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671814
Shi
Sodium barbital is a slow reve ...
Oryctolagus cuniculus
Biochem. Cell Biol.
84
142-147
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672065
Wang
Exploring the role of the acti ...
Homo sapiens
Biochemistry
45
11464-11472
2006
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672307
Zhang
Two fused proteins combining S ...
Oryctolagus cuniculus
Biochemistry (Moscow)
71
983-988
2006
-
-
-
-
1
-
-
6
-
-
-
-
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672391
Hoffman
The role of an absolutely cons ...
Chaetopterus variopedatus, Gallus gallus, Tethya aurantium
Biochim. Biophys. Acta
1764
1512-1517
2006
-
-
-
-
4
-
-
-
2
-
-
-
-
9
-
-
-
-
-
1
13
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
13
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673159
Grzyb
-
Purification and some properti ...
Clupea harengus
Comp. Biochem. Physiol. B
144B
152-158
2006
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
1
-
-
1
2
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
1
2
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673658
Zhao
Impact of intra-subunit domain ...
Oryctolagus cuniculus
FEBS Lett.
580
3835-3840
2006
-
-
-
-
8
-
-
18
-
-
-
-
-
1
-
-
-
-
-
1
9
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
18
-
-
-
-
-
-
-
-
-
1
9
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
674039
Matsushima
Comparison of kinetic constant ...
Danio rerio, Dendronephthya gigantea, Hediste diversicolor, Lethenteron camtschaticum, Mus musculus
Int. J. Biol. Macromol.
38
83-88
2006
-
-
-
-
-
-
-
22
13
-
-
-
-
16
-
-
-
-
-
-
-
-
5
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
22
13
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
674083
Wang
Heterogeneity of Escherichia c ...
Homo sapiens
IUBMB Life
58
421-428
2006
-
-
-
-
1
-
-
8
-
-
-
-
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
674384
Zonouzi
Kinetic properties of extracte ...
Mus musculus
J. Biochem. Mol. Biol.
39
426-431
2006
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
3
2
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
3
2
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
674713
Meyer
Mitochondrial creatine kinase ...
Rattus norvegicus
J. Biol. Chem.
281
37361-37371
2006
3
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675415
Du
Mixed macromolecular crowding ...
Oryctolagus cuniculus
J. Mol. Biol.
364
469-482
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675718
Pancera
Effect of pH on the adsorption ...
Oryctolagus cuniculus
J. Phys. Chem. B
110
2674-2680
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
675781
Barschak
Inhibition of the electron tra ...
Homo sapiens
Metab. Brain Dis.
21
11-19
2006
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661270
Jourden
Transition state stabilization ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1751
178-183
2005
-
-
1
-
11
-
-
14
-
1
-
1
-
2
-
-
1
1
-
2
-
-
2
-
1
-
-
14
1
-
-
2
-
-
-
-
-
1
2
-
11
-
-
-
-
14
-
1
-
1
-
-
-
1
-
2
-
-
2
-
1
-
-
14
1
-
-
-
-
-
-
-
-
-
661271
Hoffman
Over-expression, purification ...
Chaetopterus variopedatus
Biochim. Biophys. Acta
1751
184-193
2005
-
-
1
-
-
-
-
-
1
-
3
1
-
5
-
-
1
-
-
-
-
-
2
3
1
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
1
-
3
1
-
-
-
1
-
-
-
-
2
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
661523
Grzyb
Characterization of creatine k ...
Clupea harengus
Comp. Biochem. Physiol. B
140
629-634
2005
-
-
-
-
-
-
-
-
4
-
4
1
-
3
-
-
1
-
-
2
2
-
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
4
1
-
-
-
1
-
2
2
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661528
McLeish
Relating structure to mechanis ...
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Tetronarce californica
Crit. Rev. Biochem. Mol. Biol.
40
1-20
2005
-
1
1
5
-
-
27
21
10
5
4
10
-
7
-
-
1
5
-
5
1
-
26
11
-
-
-
16
2
-
-
10
-
4
-
-
1
1
10
5
-
-
-
27
-
21
10
5
4
10
-
-
-
1
-
5
1
-
26
11
-
-
-
16
2
-
-
4
-
-
-
-
-
-
661095
Novak
Isoleucine 69 and valine 325 f ...
Homo sapiens
Biochemistry
43
13766-13774
2004
-
-
1
-
5
-
-
4
-
1
-
1
-
2
-
-
1
1
-
2
1
-
4
-
1
-
-
13
1
-
-
2
-
-
-
-
-
1
2
-
5
-
-
-
-
4
-
1
-
1
-
-
-
1
-
2
1
-
4
-
1
-
-
13
1
-
-
-
-
-
-
-
-
-
661220
Belousova
Kinetics of chemical modificat ...
Bos taurus
Biochemistry
69
455-461
2004
-
-
-
-
-
-
2
1
2
2
-
1
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
1
-
-
-
-
2
1
1
2
2
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
642420
Miura
Inactivation of creatine kinas ...
Rattus norvegicus
Food Chem. Toxicol.
41
759-765
2003
-
-
-
-
-
-
4
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642424
Winnard
-
Isolation, characterization an ...
Chaenocephalus aceratus
Comp. Biochem. Physiol. B
134B
651-667
2003
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
642425
Borders
Asparagine 285 plays a key rol ...
Oryctolagus cuniculus
Protein Sci.
12
532-537
2003
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642426
Grzyb
-
Quantitative determination of ...
Clupea harengus
Comp. Biochem. Physiol. C
134C
207-213
2003
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642435
Gregor
Substrate channelling in a cre ...
Rattus norvegicus
Exp. Physiol.
88
1-6
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
660930
Tang
Effects of lactic acid and NaC ...
Oryctolagus cuniculus
Biochem. Cell Biol.
81
1-7
2003
-
-
-
-
-
-
1
-
-
2
-
1
-
2
-
-
-
-
1
2
-
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
2
-
1
-
-
-
-
1
2
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
660931
Guo
Studies on the stability of cr ...
Oryctolagus cuniculus
Biochem. Cell Biol.
81
9-16
2003
-
-
-
-
-
1
-
-
1
-
-
1
-
1
1
-
-
-
1
1
-
1
1
2
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
1
-
1
-
-
1
1
-
1
1
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
661068
Cox
Generation of an active monome ...
Oryctolagus cuniculus
Biochemistry
42
1863-1871
2003
-
-
1
-
5
-
2
1
1
1
10
1
-
2
-
-
1
1
-
2
-
-
1
3
1
-
4
-
1
-
-
2
-
-
-
-
-
1
2
-
5
-
-
2
-
1
1
1
10
1
-
-
-
1
-
2
-
-
1
3
1
-
4
-
1
-
-
-
-
-
-
-
-
-
661901
Pilla
Kinetic studies on the inhibit ...
Rattus norvegicus
Int. J. Dev. Neurosci.
21
145-151
2003
-
-
-
-
-
-
4
3
-
1
-
2
-
4
-
-
-
-
-
2
-
-
3
-
1
-
-
-
1
-
-
2
6
-
-
-
-
-
2
-
-
-
-
4
6
3
-
1
-
2
-
-
-
-
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662511
Kanemitsu
Mitochondrial creatine kinase ...
Homo sapiens
J. Chromatogr. B
783
191-197
2003
-
-
-
-
-
-
1
2
1
-
-
1
-
1
-
-
1
-
-
2
-
-
1
-
1
-
1
-
-
1
-
1
-
5
-
-
-
-
1
-
-
-
-
1
-
2
1
-
-
1
-
-
-
1
-
2
-
-
1
-
1
-
1
-
-
1
-
5
-
-
-
-
-
-
662524
Birkedal
Creatine kinase and mitochondr ...
Gadus morhua, Oncorhynchus mykiss, Trachemys scripta elegans
J. Comp. Physiol. B
173
493-499
2003
-
-
-
-
-
-
-
3
4
-
-
3
-
8
-
-
3
-
-
5
-
-
3
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
6
-
-
-
-
-
-
3
4
-
-
3
-
-
-
3
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662723
Hahn
Aggregation and folding of rec ...
Homo sapiens
J. Protein Chem.
22
563-570
2003
-
-
1
-
-
-
-
-
-
1
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642433
Bonz
Functional properties and [Ca( ...
Mus musculus
Biochem. Biophys. Res. Commun.
298
163-168
2002
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642437
Wang
Expression of Torpedo californ ...
Tetronarce californica
Protein Expr. Purif.
26
89-95
2002
-
-
-
-
-
-
-
4
3
-
-
-
-
6
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
3
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642441
Lahiri
The 2.1.ANG. Structure of Torp ...
Tetronarce californica
Biochemistry
41
13861-13867
2002
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642429
Ye
Myocardial creatine kinase kin ...
Canis lupus familiaris
Am. J. Physiol.
281
H376-H386
2001
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642431
Harder
Isolation and characterization ...
Danio rerio
Biochem. Cell Biol.
79
779-782
2001
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642438
Lipskaya
Mitochondrial creatine kinase: ...
Bos taurus, Columba livia
Biochemistry
66
1098-1111
2001
-
-
-
-
-
-
-
8
2
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
8
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
642446
Zhu
Relationship between Kinetic a ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
285
857-862
2001
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642430
Schlattner
Divergent enzyme kinetics and ...
Homo sapiens
Biol. Chem.
381
1063-1070
2000
-
-
-
-
-
-
-
4
2
-
3
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
2
-
3
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
642436
Kanemitsu
Characterization of two types ...
Homo sapiens
Electrophoresis
21
266-270
2000
-
-
-
-
-
-
-
2
1
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
642439
Mourad-Terzian
Creatine kinase isoenzymes spe ...
Homo sapiens
FEBS Lett.
475
22-26
2000
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642442
Eder
Crystal structure of human ubi ...
Homo sapiens
Proteins
39
216-225
2000
-
-
-
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642421
Buist
-
Temperature dependence of the ...
Rattus norvegicus
Can. J. Chem.
77
1887-1891
1999
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642423
Gregor
Creatine kinase reaction in sk ...
Rattus norvegicus
Physiol. Res.
48
27-35
1999
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642443
Tang
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. D
55
669-670
1999
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642444
Eder
Crystal structure of brain-typ ...
Gallus gallus
Protein Sci.
8
2258-2269
1999
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642427
Ventura-Clapier
Functional coupling of creatin ...
Columba livia, Frog, Gallus gallus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Mol. Cell. Biochem.
184
231-247
1998
-
-
-
-
-
-
-
-
6
-
-
6
-
8
-
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642428
Yang
Reactivation kinetics of 5,5'- ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1388
190-198
1998
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642440
Gellerich
Dextran strongly increases the ...
Rattus norvegicus
Eur. J. Biochem.
254
172-180
1998
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642445
Rao
Crystal structure of rabbit mu ...
Oryctolagus cuniculus
FEBS Lett.
439
133-137
1998
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642422
Walterscheid-Muller
Purification and characterizat ...
Homo sapiens
J. Mol. Cell. Cardiol.
29
921-927
1997
-
-
-
-
-
-
-
-
2
-
3
-
-
3
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
642434
Couthon
High salt concentrations induc ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1339
277-288
1997
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642432
Tombes
Isolation and characterization ...
Strongylocentrotus purpuratus
Methods Cell Biol.
47
467-472
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642371
Wyss
Mitochondrial creatine kinase: ...
Bos taurus, Columba livia, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus, Strongylocentrotus purpuratus, Sus scrofa
Biochim. Biophys. Acta
1102
119-166
1992
-
8
-
8
-
-
-
8
24
-
8
8
-
8
-
-
8
8
-
80
-
-
16
-
-
-
-
-
14
-
-
-
-
8
-
-
8
-
-
8
-
-
-
-
-
8
24
-
8
8
-
-
-
8
-
80
-
-
16
-
-
-
-
-
14
-
-
8
-
-
-
-
-
-
642372
Schnyder
Crystallization of mitochondri ...
Gallus gallus
J. Biol. Chem.
266
5318-5322
1991
-
-
-
1
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642412
Nakagawa
-
Enzymic properties of fish mus ...
Cyprinus carpio, Pagrus major, Scomber japonicus
Comp. Biochem. Physiol. B
98
349-354
1991
-
-
-
-
-
-
6
6
-
3
-
-
-
3
-
-
3
-
-
3
-
-
3
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
6
-
3
-
-
-
-
-
3
-
3
-
-
3
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
642373
Schnyder
Crystallization and preliminar ...
Gallus gallus
J. Mol. Biol.
216
809-812
1990
-
-
-
1
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
3
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642374
Wyss
Mitochondrial creatine kinase ...
Gallus gallus
J. Biol. Chem.
265
15900-15908
1990
-
-
-
-
-
-
-
1
2
-
3
-
-
3
-
-
1
-
-
3
1
-
1
1
2
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
3
-
-
-
-
1
-
3
1
-
1
1
2
-
1
-
2
-
-
-
-
-
-
-
-
-
642375
Schlegel
Native mitochondrial creatine ...
Gallus gallus
J. Biol. Chem.
263
16942-16953
1988
-
-
-
-
-
-
-
-
3
-
2
-
-
3
-
-
1
-
-
2
1
2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
1
-
2
1
2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642376
Schnyder
Native mitochondrial creatine ...
Gallus gallus
J. Biol. Chem.
263
16954-16962
1988
-
-
-
-
-
1
-
-
2
-
3
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
3
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642410
Hossle
Distinct tissue specific mitoc ...
Gallus gallus
Biochem. Biophys. Res. Commun.
151
408-416
1988
-
-
1
-
-
-
-
-
2
-
1
-
-
2
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642413
Robert
Purification and characterizat ...
Xenopus laevis
Biochem. Genet.
26
543-555
1988
-
-
-
-
-
-
-
-
2
-
2
-
-
4
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642414
Schneider
Kinetic characterization of hu ...
Homo sapiens
Enzyme
39
220-226
1988
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642377
Brooks
Homogeneous chicken heart mito ...
Gallus gallus
Anal. Biochem.
164
190-198
1987
-
-
-
-
-
-
-
-
2
-
2
-
-
4
-
-
1
-
-
2
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642418
Tombes
Enzyme termini of a phosphocre ...
Strongylocentrotus purpuratus
J. Biol. Chem.
262
16011-16019
1987
-
-
-
-
-
-
-
1
1
-
4
-
-
3
-
-
1
-
-
4
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
4
-
-
-
-
1
-
4
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642378
Hershenson
Purification and crystallizati ...
Oryctolagus cuniculus
J. Biol. Chem.
261
3732-3736
1986
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642415
Afolayan
Isolation and properties of cr ...
Eidolon helvum
Comp. Biochem. Physiol. B
85
463-468
1986
-
-
-
-
-
-
1
-
-
3
2
-
-
3
-
1
1
-
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
3
2
-
-
-
1
1
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642416
Gray
Purification and characterizat ...
Ginglymostoma cirratum
Comp. Biochem. Physiol. B
83
613-620
1986
-
-
-
-
-
-
2
4
-
1
-
-
-
6
-
-
1
-
-
4
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
1
-
-
-
-
-
1
-
4
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
642379
Barrantes
Isolation and characterization ...
Discopyge tschudii, Torpedo marmorata
J. Biol. Chem.
260
3024-3034
1985
-
-
-
-
-
-
-
4
3
2
-
-
-
3
-
-
2
-
-
3
2
-
2
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
3
2
-
-
-
-
-
2
-
3
2
-
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
642380
Vaidya
Purification of five creatine ...
Homo sapiens
Biochim. Biophys. Acta
790
230-237
1984
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
5
1
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
5
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
642381
George
Purification and characterizat ...
Canis lupus familiaris
J. Biol. Chem.
259
2667-2674
1984
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
1
-
-
2
2
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
2
-
1
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
642382
Rudge
-
Thermal stability of immobiliz ...
Oryctolagus cuniculus
Biochem. Soc. Trans.
12
311-313
1984
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642383
Grace
Purification and characterizat ...
Homo sapiens
J. Biol. Chem.
258
15346-15354
1983
-
-
-
-
-
-
-
-
3
-
1
-
-
3
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642384
Gilliland
Crystallization and preliminar ...
Bos taurus
J. Mol. Biol.
170
791-793
1983
-
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642385
Blum
Mitochondrial creatine kinase ...
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Papio anubis, Rattus norvegicus, Sus scrofa, trout
J. Biochem.
94
1247-1257
1983
-
-
-
1
-
-
-
4
9
8
2
-
-
9
-
-
1
-
-
9
2
1
8
8
-
-
-
-
9
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
9
8
2
-
-
-
-
1
-
9
2
1
8
8
-
-
-
-
9
-
1
-
-
-
-
-
-
-
642386
Takasawa
Properties of three creatine k ...
Sus scrofa
J. Biochem.
93
389-395
1983
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
642388
Gerhardt
-
Creatine kinase ...
Homo sapiens
Methods Enzym. Anal. ,3rd Ed. (Bergmeyer,H. U. ,ed. )
3
508-510
1983
-
1
-
-
-
-
15
-
2
2
-
-
-
1
-
-
-
-
1
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
15
-
-
2
2
-
-
-
-
-
-
1
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642389
Kumar
Purification and characterizat ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
111
156-165
1983
-
-
-
-
-
-
3
1
1
-
1
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
1
1
-
1
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
642419
Kenyon
Creatine kinase: structure-act ...
Mammalia
Adv. Enzymol. Relat. Areas Mol. Biol.
54
367-426
1983
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642390
Olson
Purification and cell-free tra ...
Mus musculus
Biochem. Biophys. Res. Commun.
108
715-723
1982
-
-
-
-
-
-
-
-
1
-
2
-
-
2
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642391
Roberts
-
Purification of human and cani ...
Canis lupus familiaris, Homo sapiens
Methods Enzymol.
90
185-195
1982
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
2
-
-
3
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
3
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642387
Takasawa
-
Isolation and properties of cr ...
Sus scrofa
J. Biochem.
90
195-204
1981
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642392
Takasawa
Crystallization and properties ...
Equus caballus
J. Biochem.
89
1619-1631
1981
-
-
-
-
-
-
2
-
1
-
3
-
-
2
-
-
-
-
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642393
Roerts
Purification of mitochondrial ...
Canis lupus familiaris
J. Biol. Chem.
255
2870-2877
1980
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
2
1
1
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
642394
Reddy
Inhibition of creatine kinase ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
569
109-113
1979
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642395
Hall
Mitochondrial creatine kinase. ...
Bos taurus
Biochemistry
18
1745-1751
1979
-
-
-
-
-
-
-
4
2
1
2
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
2
1
2
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
642396
Fisher
Purification of the creatine k ...
Lepomis cyanellus
Anal. Biochem.
94
89-95
1979
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642397
Herasymowych
Isolation, purification and ch ...
Bos taurus, Oryctolagus cuniculus
Biochim. Biophys. Acta
534
38-47
1978
-
-
-
-
-
-
-
3
-
-
2
-
-
3
-
-
-
-
-
3
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
3
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642398
Burgess
Creatine kinase. A new crystal ...
Oryctolagus cuniculus
J. Mol. Biol.
123
691-695
1978
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642399
Reddy
Inhibition of rabbit muscle cr ...
Oryctolagus cuniculus
Biochem. Soc. Trans.
6
553-555
1978
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642400
Saks
The localization of the MM iso ...
Rattus norvegicus
Biochim. Biophys. Acta
465
550-558
1977
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
1
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642401
Hall
Purification of mitochondrial ...
Bos taurus
Biochem. Biophys. Res. Commun.
76
950-956
1977
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642402
Madelian
Properties of a structurally a ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
184
103-110
1977
-
-
-
-
-
-
2
-
-
-
1
-
-
1
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642403
Saks
Studies of energy transport in ...
Rattus norvegicus
Eur. J. Biochem.
57
273-290
1975
-
-
-
-
-
-
-
4
1
1
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
1
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642417
Storey
-
Purification and properties of ...
Trachemys scripta
Int. J. Biochem.
6
54-59
1975
1
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
1
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
642404
Gercken
Inhibition of creatine kinase ...
Oryctolagus cuniculus
FEBS Lett.
46
87-91
1974
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642405
Witteveen
Kinetic properties of the isoe ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
71
1384-1387
1974
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642406
Schimerlik
Inhibition of creatine kinase ...
Oryctolagus cuniculus
J. Biol. Chem.
248
8418-8423
1973
-
-
-
-
-
-
3
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642407
Keutel
Studies on adenosine triphosph ...
Bos taurus, Homo sapiens, Oryctolagus cuniculus
Arch. Biochem. Biophys.
150
648-678
1972
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
3
-
-
3
3
-
3
-
-
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
3
3
-
3
-
-
-
4
-
-
-
4
-
-
-
-
-
-
-
642408
Simonarson
Purification and properties of ...
Scyliorhinus canicula
Biochem. J.
128
1241-1253
1972
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642411
Gosselin-Rrey
Isolation and molecular proper ...
Cyprinus carpio
Biochim. Biophys. Acta
221
241-254
1970
-
-
-
1
-
-
1
-
-
-
1
-
-
2
-
1
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642447
Moreland
Phosphagen kinases and evoluti ...
echinodermata
Nature
214
458-462
1967
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642409
Kuby
-
ATP-creatine transphosphorylas ...
Mammalia
The Enzymes,2nd. Ed. (Boyer,P. D. ,ed. )
6
515-603
1962
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-