BRENDA - Enzyme Database
show all sequences of 2.7.2.8

Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members

Marcos, E.; Crehuet, R.; Bahar, I.; PLoS Comput. Biol. 7(9), e1002201 (2011)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Reaction
Reaction
Commentary
Organism
ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate
using an elastic network model representation a normal mode analysis shows that the conformational mechanisms for substrate binding by NAGK strongly correlate with the intrinsic dynamics of the enzyme in the unbound form. The conformational change observed between the open and closed forms of EcNAGK are essentially accomplished by movements along a small subset of modes
Escherichia coli
Subunits
Subunits
Commentary
Organism
dimer
-
Escherichia coli
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Escherichia coli
Other publictions for EC 2.7.2.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738801
Zhao
Controlling the transcription ...
Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5
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2016
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1
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1
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2
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4
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2
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1
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1
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1
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1
1
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8
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1
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1
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2
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2
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1
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1
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1
1
-
-
-
735596
Zhao
Structure of N-acetyl-L-glutam ...
Maricaulis maris, Maricaulis maris MCS10, Xanthomonas campestris, Xanthomonas campestris 8004
Biochem. Biophys. Res. Commun.
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585-590
2013
-
-
2
1
10
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2
-
-
1
-
4
-
7
-
-
2
1
-
-
7
-
6
-
2
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2
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2
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2
2
1
10
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2
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1
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4
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2
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7
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6
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2
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-
2
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3
3
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721268
Xu
Site-directed mutagenesis and ...
Corynebacterium crenatum
Amino Acids
43
255-266
2012
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1
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5
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1
5
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1
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1
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1
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1
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12
1
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6
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1
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5
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6
1
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5
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1
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1
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1
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12
1
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1
1
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722087
Xu
Site-directed mutagenesis stud ...
Corynebacterium glutamicum
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64
164-172
2012
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1
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16
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1
17
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1
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2
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1
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1
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32
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17
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1
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16
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1
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17
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1
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32
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Marcos
Changes in dynamics upon oligo ...
Escherichia coli
PLoS Comput. Biol.
7(9)
e1002201
2011
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642359
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659704
Marco-Marin
Site-directed mutagenesis of E ...
Escherichia coli
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334
459-476
2003
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4
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1
10
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2
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642363
Ramon-Maiques
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2002
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McKay
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N-acetylglutamate 5-phosphotra ...
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642354
Denes
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N-Acetylglutamate-5-phosphotra ...
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Vogel
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Farago
Mechanism of arginine biosynth ...
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N-acetyl-gamma-glutamokinase a ...
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