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Literature summary for 2.7.2.4 extracted from

  • Curien, G.; Ravanel, S.; Robert, M.; Dumas, R.
    Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity (2005), J. Biol. Chem., 280, 41178-41183.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-alanine 13fold activation at 2.5 mM Arabidopsis thaliana
L-alanine 3fold activation at 2.5 mM Arabidopsis thaliana
L-cysteine 13fold activation at 2.5 mM Arabidopsis thaliana
L-cysteine 3fold activation at 2.5 mM Arabidopsis thaliana
L-isoleucine 13fold activation at 2.5 mM Arabidopsis thaliana
L-isoleucine 3fold activation at 2.5 mM Arabidopsis thaliana
L-leucine 4fold activation at 2.5 mM Arabidopsis thaliana
L-serine 13fold activation at 2.5 mM Arabidopsis thaliana
L-serine 3fold activation at 2.5 mM Arabidopsis thaliana
L-valine 13fold activation at 2.5 mM Arabidopsis thaliana
L-valine 3fold activation at 2.5 mM Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Arabidopsis thaliana

General Stability

General Stability Organism
pure protein , quickly frozen in N2 can be stored at -80°C for several months without any loss of activity Arabidopsis thaliana
pure protein, quickly frozen in N2 can be stored at -80°C for several months without any loss of activity Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
L-leucine allosteric effector Arabidopsis thaliana
L-threonine in the presence of 1 mM aspartate and 2 mM ATP Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.42
-
ATP 50 mM aspartate, presence of alanine Arabidopsis thaliana
0.48
-
ATP 50 mM aspartate, presence of alanine Arabidopsis thaliana
1.5
-
L-aspartate 20 mM ATP, presence of alanine Arabidopsis thaliana
2.2
-
ATP 50 mM aspartate, absence of alanine Arabidopsis thaliana
2.3
-
L-aspartate 20 mM ATP, presence of alanine Arabidopsis thaliana
2.6
-
L-aspartate 20 mM ATP, absence of alanine Arabidopsis thaliana
6.15
-
L-aspartate 20 mM ATP, absence of alanine Arabidopsis thaliana
6.5
-
ATP 50 mM aspartate, absence of alanine Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate Arabidopsis thaliana
-
ADP + 4-phospho-L-aspartate
-
?
ATP + L-aspartate Arabidopsis thaliana
-
ADP + phospho-L-aspartate
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Arabidopsis thaliana

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate
-
Arabidopsis thaliana ADP + 4-phospho-L-aspartate
-
?
ATP + L-aspartate
-
Arabidopsis thaliana ADP + phospho-L-aspartate
-
?

Synonyms

Synonyms Comment Organism
AK-HSDH I
-
Arabidopsis thaliana
aspartate kinase I also acts as homoserine dehydrogenase (EC 1.1.1.3) Arabidopsis thaliana
aspartate kinase II also acts as homoserine dehydrogenase (EC 1.1.1.3) Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.049
-
L-threonine in the presence of 1 mM aspartate and 2 mM ATP Arabidopsis thaliana
0.091
-
L-threonine in the presence of 1 mM aspartate and 2 mM ATP Arabidopsis thaliana
1.1
-
L-leucine
-
Arabidopsis thaliana