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Literature summary for 2.7.2.3 extracted from
- Studies with inhibitors of the glycolytic enzyme phosphoglycerate kinase for potential treatment of cardiovascular and respiratory disorders (1996), J. Pharm. Pharmacol., 48, 201-205.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of the enzyme can provide a method of treatment for cardiovascular and respiratory disorders, construction of possible specific fluoro-phosphonate inhibitors | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Saccharomyces cerevisiae | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane | phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae |  |
| 1,4-bis(difluoro)-1,4-diphospho-diethylether | phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae | |
| additional information | - |
Homo sapiens | |
| additional information | inhibitory effect of phosphonate analogues of 1,3-diphosphoglycerate, overview | Saccharomyces cerevisiae |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | - |
Homo sapiens | ADP + 1,3-diphosphoglycerate | - |
r | |
| ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 1,3-diphosphoglycerate | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
| 7.5 | - |
assay at | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Homo sapiens | |
| ADP | - |
Saccharomyces cerevisiae | |
| ATP | true substrate is the magnesium complexes of ATP | Homo sapiens | |
| ATP | true substrate is the magnesium complexes of ATP | Saccharomyces cerevisiae | |
| ATP | required as phosphate donor | Homo sapiens | |
| ATP | required as phosphate donor | Saccharomyces cerevisiae | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki-values for phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae | |
| 1.44 | 1.5 | 1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane | pH 7.5, 25°C | Saccharomyces cerevisiae | |
| 3.25 | 3.3 | 1,4-bis(difluoro)-1,4-diphospho-diethylether | pH 7.5, 25°C | Saccharomyces cerevisiae | |
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