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Literature summary for 2.7.2.18 extracted from
- Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus (2014), Proc. Natl. Acad. Sci. USA, 111, 10532-10537 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Staphylococcus aureus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 240000 | - |
FakA, gel filtration | Staphylococcus aureus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
| Staphylococcus aureus USA300 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myristic acid | - |
Staphylococcus aureus | ADP + myristyl phosphate | - |
? |  |
| ATP + myristic acid | - |
Staphylococcus aureus USA300 | ADP + myristyl phosphate | - |
? | |
| ATP + oleic acid | - |
Staphylococcus aureus | ADP + oleyl phosphate | - |
? | |
| ATP + oleic acid | - |
Staphylococcus aureus USA300 | ADP + oleyl phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | FakA, analytical ultracentrifugation | Staphylococcus aureus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FA kinase | - |
Staphylococcus aureus |
| FAK | - |
Staphylococcus aureus |
| fakA | FakA provides the ATP binding domain and interacts with two distinct FakB protein to produce acyl phosphate | Staphylococcus aureus |
| fakB | FakB is a fatty acid binding protein. FakB1 selectively binds saturated fatty acids whereas FakB2 prefers unsaturated fatty acids | Staphylococcus aureus |
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Release 2023.1 (January 2023)
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