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Literature summary for 2.7.2.18 extracted from

  • Ericson, M.E.; Subramanian, C.; Frank, M.W.; Rock, C.O.
    Role of fatty acid kinase in cellular lipid homeostasis and SaeRS-dependent virulence factor expression in Staphylococcus aureus (2017), mBio, 8, e00988-17 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus USA300
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + oleate
-
 Staphylococcus aureus ADP + oleyl phosphate
-
 ?
ATP + oleate
-
 Staphylococcus aureus USA300 ADP + oleyl phosphate
-
 ?
additional information the enzyme does not phosphorylate SaeS or SaeR Staphylococcus aureus ?
-
-
additional information the enzyme does not phosphorylate SaeS or SaeR Staphylococcus aureus USA300 ?
-
-

Synonyms

Synonyms Comment Organism
FA kinase
-
 Staphylococcus aureus
fakA kinase domain Staphylococcus aureus
FakAB
-
 Staphylococcus aureus

General Information

General Information Comment Organism
metabolism the enzyme activates SaeRS-dependent virulence factor production by lowering inhibitory fatty acid levels. Thus, the enzyme plays a role in cellular lipid homeostasis by activating fatty acid for incorporation into phospholipid, and it indirectly regulates SaeRS signaling by maintaining a low intracellular fatty acid pool Staphylococcus aureus