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Literature summary for 2.7.13.3 extracted from

  • Duan, Y.; Ge, C.; Liu, S.; Wang, J.; Zhou, M.
    A two-component histidine kinase Shk1 controls stress response, sclerotial formation and fungicide resistance in Sclerotinia sclerotiorum (2013), Mol. Plant Pathol., 14, 708-718.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene SS1G_12694, DNa and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis Sclerotinia sclerotiorum

Protein Variants

Protein Variants Comment Organism
additional information generation of a Shk1 deletion mutant, all the defects are restored by genetic complementation of the Shk1 deletion mutant with the wild-type Shk1 gene Sclerotinia sclerotiorum

Organism

Organism UniProt Comment Textmining
Sclerotinia sclerotiorum A7F519
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Sclerotinia sclerotiorum HA61 A7F519
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Source Tissue

Source Tissue Comment Organism Textmining
sclerotium
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Sclerotinia sclerotiorum
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Synonyms

Synonyms Comment Organism
Shk1
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Sclerotinia sclerotiorum
SS1G_12694
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Sclerotinia sclerotiorum
two-component histidine kinase
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Sclerotinia sclerotiorum

General Information

General Information Comment Organism
evolution histidine kinase Shk1 is a member of the histidine kinase class III, whose members are all known to signal through the high-osmolarity glycerol mitogen-activated protein kinase Sclerotinia sclerotiorum
malfunction disruption of Shk1 results in resistance to phenylpyrrole and dicarboximide fungicides and increases sensitivity to hyperosmotic stress and H2O2-induced oxidative stress. The Shk1 mutant shows a significant reduction in vegetative hyphal growth and is unable to produce sclerotia. The Shk1 mutant shows no change in virulence. All the defects are restored by genetic complementation of the Shk1 deletion mutant with the wild-type Shk1 gene Sclerotinia sclerotiorum
physiological function two-component histidine kinases (HKs) regulate responses to environmental stimuli in bacteria and eukaryotes, including yeasts, plants, slime moulds and filamentous fungi. Fungal histidine kinases are involved in osmotic and oxidative stress responses, hyphal development, fungicide sensitivity and virulence. The two-component histidine kinase Shk1 controls stress response, sclerotial formation and fungicide resistance in Sclerotinia sclerotiorum. The expression of SsHOG1 (the last kinase of the Hog pathway) and glycerol accumulation are regulated by the Shk1 gene, but PAK (p21-activated kinase) is not Sclerotinia sclerotiorum