Cloned (Comment) | Organism |
---|---|
gene SS1G_12694, DNa and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis | Sclerotinia sclerotiorum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a Shk1 deletion mutant, all the defects are restored by genetic complementation of the Shk1 deletion mutant with the wild-type Shk1 gene | Sclerotinia sclerotiorum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sclerotinia sclerotiorum | A7F519 | - |
- |
Sclerotinia sclerotiorum HA61 | A7F519 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sclerotium | - |
Sclerotinia sclerotiorum | - |
Synonyms | Comment | Organism |
---|---|---|
Shk1 | - |
Sclerotinia sclerotiorum |
SS1G_12694 | - |
Sclerotinia sclerotiorum |
two-component histidine kinase | - |
Sclerotinia sclerotiorum |
General Information | Comment | Organism |
---|---|---|
evolution | histidine kinase Shk1 is a member of the histidine kinase class III, whose members are all known to signal through the high-osmolarity glycerol mitogen-activated protein kinase | Sclerotinia sclerotiorum |
malfunction | disruption of Shk1 results in resistance to phenylpyrrole and dicarboximide fungicides and increases sensitivity to hyperosmotic stress and H2O2-induced oxidative stress. The Shk1 mutant shows a significant reduction in vegetative hyphal growth and is unable to produce sclerotia. The Shk1 mutant shows no change in virulence. All the defects are restored by genetic complementation of the Shk1 deletion mutant with the wild-type Shk1 gene | Sclerotinia sclerotiorum |
physiological function | two-component histidine kinases (HKs) regulate responses to environmental stimuli in bacteria and eukaryotes, including yeasts, plants, slime moulds and filamentous fungi. Fungal histidine kinases are involved in osmotic and oxidative stress responses, hyphal development, fungicide sensitivity and virulence. The two-component histidine kinase Shk1 controls stress response, sclerotial formation and fungicide resistance in Sclerotinia sclerotiorum. The expression of SsHOG1 (the last kinase of the Hog pathway) and glycerol accumulation are regulated by the Shk1 gene, but PAK (p21-activated kinase) is not | Sclerotinia sclerotiorum |