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Literature summary for 2.7.13.3 extracted from

  • Inclan, Y.F.; Laurent, S.; Zusman, D.R.
    The receiver domain of FrzE, a CheA-CheY fusion protein, regulates the CheA histidine kinase activity and downstream signalling to the A- and S-motility systems of Myxococcus xanthus (2008), Mol. Microbiol., 68, 1328-1339.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Tuner cells Myxococcus xanthus

Organism

Organism UniProt Comment Textmining
Myxococcus xanthus
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein FrzCD stimulates FrzE autophosphorylation Myxococcus xanthus

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography Myxococcus xanthus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FrzE autophosphorylates the kinase domain at His-49, and phosphoryl groups are transferred to aspartate residues (Asp-52 and Asp-220) in the two receiver domains of FrzA. The FrzE receiver domain inhibits autophosphorylation of the FrzE kinase domain Myxococcus xanthus ?
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?

Synonyms

Synonyms Comment Organism
FrzE hybrid protein consisting of a CheA histidine kinase and a CheY receiver domain Myxococcus xanthus

Cofactor

Cofactor Comment Organism Structure
ATP
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Myxococcus xanthus