Literature summary for 2.7.13.3 extracted from

Kaspar, S.; Perozzo, R.; Reinelt, S.; Meyer, M.; Pfister, K.; Scapozza, L.; Bott, M.
The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor (1999), Mol. Microbiol., 33, 858-872.

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Protein Variants

Protein Variants	Comment	Organism
D56N	phosphorylation of CitB is inhibited by a D56N exchange. In the presence of ATP, CitB-D56N forms a stable complex with MalE-CitAC	Klebsiella pneumoniae
H350L	autokinase activity of CitA is abolished by an H350L exchange	Klebsiella pneumoniae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	CitA represents a membrane-bound sensor kinase consisting of a periplasmic domain flanked by two transmembrane helices, a linker domain and the conserved kinase or transmitter domain	Klebsiella pneumoniae	16020	-

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	P52687	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CitB + ATP	a fusion protein MalE-CitAC is composed of the maltose-binding protein and the CitA kinase domain shows constitutive autokinase activity and transfers the gamma-phosphate group of ATP to its cognate response regulator CitB	Klebsiella pneumoniae	?	-	?

Synonyms

Synonyms	Comment	Organism
sensor kinase citA	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)