Literature summary for 2.7.12.1 extracted from

Kisaka, J.; Ratner, L.; Kyei, G.
The dual-specificity kinase DYRK1A modulates the levels of cyclin L2 to control HIV replication in macrophages (2020), J. Virol., 94, e01583 .

Search for more literature for 2.7.12.1

Application

Application	Comment	Organism
medicine	DYRK1A controls cyclin L2 expression, leading to restriction of HIV replication in macrophages	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	cyclin L2 and DYRK1A colocalize in the nucleus	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13627	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + cyclin L2	-	Homo sapiens	ADP + phosphorylated cyclin L2	-	?

Synonyms

Synonyms	Comment	Organism
dual specificity tyrosine-phosphorylation-regulated kinase 1A	-	Homo sapiens
DYRK1A	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	cyclin L2promotes HIV-1 replication through interactions with DYRK1A. Knockdown or inhibition of DYRK1A increases HIV-1 replication in macrophages, while depletion of cyclin L2 decreases HIV-1 replication. Depletion of DYRK1A increases expression levels of cyclin L2. Mutations of cyclin L2 at serine residues preceding proline abolishes phosphorylation by DYRK1A, significantly stabilizes cyclin L2 and increases HIV-1 replication in macrophages	Homo sapiens

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Release 2023.1 (January 2023)