BRENDA - Enzyme Database show
show all sequences of 2.7.12.1

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression

Qian, W.; Jin, N.; Shi, J.; Yin, X.; Jin, X.; Wang, S.; Cao, M.; Iqbal, K.; Gong, C.X.; Liu, F.; J. Alzheimers Dis. 37, 529-538 (2013)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
K188R
site-directed mutagenesis, catalytically inactive mutant
Homo sapiens
additional information
construction of three deletion mutations of Dyrk1A from C-terminus, including Dyrk1A1-616 without S/T region, Dyrk1A1-588 without His repeats and S/T region, and Dyrk1A1-474 without PEST, His repeats, and S/T region for investigation whether C-terminus of Dyrk1A is responsible for the regulation of tau expression. All three C-terminal deletion mutations of Dyrk1A enhance the expression of tau to a much less extent as compared with the full length Dyrk1A
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
Dyrk1A contains a nuclear targeting signal sequence
Homo sapiens
5634
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q13627
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HEK-293FT cell
-
Homo sapiens
-
neuronal cell
-
Homo sapiens
-
Subunits
Subunits
Commentary
Organism
More
Dyrk1A contains a nuclear targeting signal sequence, a protein kinase domain, a PEST domain (protein domain that is enriched in proline (P), glutamic acid (E), serine (S), and threonine (T) residues), 13 consecutive histidine residues (His repeats) and a serine/threonine rich segment (S/T). The PEST region is located in the C terminus of the catalytic domain. A stretch of 13 histidines located between 607 and 619 amino acid residues follows subsequently a segment of 14 serine/threonine residues
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
K188R
site-directed mutagenesis, catalytically inactive mutant
Homo sapiens
additional information
construction of three deletion mutations of Dyrk1A from C-terminus, including Dyrk1A1-616 without S/T region, Dyrk1A1-588 without His repeats and S/T region, and Dyrk1A1-474 without PEST, His repeats, and S/T region for investigation whether C-terminus of Dyrk1A is responsible for the regulation of tau expression. All three C-terminal deletion mutations of Dyrk1A enhance the expression of tau to a much less extent as compared with the full length Dyrk1A
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
Dyrk1A contains a nuclear targeting signal sequence
Homo sapiens
5634
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HEK-293FT cell
-
Homo sapiens
-
neuronal cell
-
Homo sapiens
-
Subunits (protein specific)
Subunits
Commentary
Organism
More
Dyrk1A contains a nuclear targeting signal sequence, a protein kinase domain, a PEST domain (protein domain that is enriched in proline (P), glutamic acid (E), serine (S), and threonine (T) residues), 13 consecutive histidine residues (His repeats) and a serine/threonine rich segment (S/T). The PEST region is located in the C terminus of the catalytic domain. A stretch of 13 histidines located between 607 and 619 amino acid residues follows subsequently a segment of 14 serine/threonine residues
Homo sapiens
General Information
General Information
Commentary
Organism
physiological function
enzyme Dyrk1A interacts with and phosphorylates diverse cellular proteins including transcription and splicing factors. Dyrk1A enhances tau expression and regulates expression of endogenous tau in neuronal cells, mechanism, overview. Dyrk1A does not enhance tau gene transcription, but increases tau mRNA stability. The enhancement does not require the kinase activity of Dyrk1A, the inactive enzyme mutant K188R also increases tau expression. Dyrk1A increases the expression of tau isoforms containing exon 10 to a larger extent than isoforms lacking exon 10. Dyrk1A is overexpressed in Down syndrome and may play a critical role in the early onset of tau pathology in this disease
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
enzyme Dyrk1A interacts with and phosphorylates diverse cellular proteins including transcription and splicing factors. Dyrk1A enhances tau expression and regulates expression of endogenous tau in neuronal cells, mechanism, overview. Dyrk1A does not enhance tau gene transcription, but increases tau mRNA stability. The enhancement does not require the kinase activity of Dyrk1A, the inactive enzyme mutant K188R also increases tau expression. Dyrk1A increases the expression of tau isoforms containing exon 10 to a larger extent than isoforms lacking exon 10. Dyrk1A is overexpressed in Down syndrome and may play a critical role in the early onset of tau pathology in this disease
Homo sapiens
Other publictions for EC 2.7.12.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741257
Yan
Low expression of DYRK2 (dual ...
Homo sapiens
PLoS ONE
11
e0159954
2016
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741425
Miao
Utility of the dual-specificit ...
Homo sapiens
Sci. Rep.
6
33121
2016
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2
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739790
Alexeeva
The structure of a dual-specif ...
Homo sapiens
Acta Crystallogr. Sect. D
71
1207-1215
2015
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1
1
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1
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2
2
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740451
Kim
Arabidopsis Yak1 protein (AtYa ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
FEBS Lett.
589
3321-3327
2015
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1
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1
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10
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1
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1
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2
2
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740550
Leal
Hologram QSAR models of a seri ...
Homo sapiens
Int. J. Mol. Sci.
16
5235-5253
2015
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1
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46
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46
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1
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741084
Zhou
Role of dual specificity tyros ...
Homo sapiens
Oncotarget
6
30745-30761
2015
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1
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2
2
1
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741205
Kajikawa
Algal dual-specificity tyrosin ...
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii C-9
Plant Physiol.
168
752-764
2015
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1
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3
3
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740243
Kaistha
Key role of dual specificity k ...
Homo sapiens
Br. J. Cancer
111
1780-1787
2014
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1
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1
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2
2
1
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740141
Coombs
Small-molecule pyrimidine inhi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
23
3654-3661
2013
-
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50
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740286
Wippich
Dual specificity kinase DYRK3 ...
Homo sapiens
Cell
152
791-805
2013
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1
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10
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740566
Qian
Dual-specificity tyrosine phos ...
Homo sapiens
J. Alzheimers Dis.
37
529-538
2013
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1
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740800
Pan
Pharmacophore and 3D-QSAR char ...
Homo sapiens
J. Chem. Inf. Model.
53
938-947
2013
-
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55
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741023
Abekhoukh
Dyrk1A, a serine/threonine kin ...
Mus musculus
Mol. Neurobiol.
47
105-116
2013
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1
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2
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740700
Arora
Unveiling the novel dual speci ...
Bacillus anthracis
J. Biol. Chem.
287
26749-26763
2012
1
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7
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1
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4
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740702
Yin
Dual-specificity tyrosine phos ...
Rattus norvegicus
J. Biol. Chem.
287
30497-30506
2012
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740695
Huang
Invasion of Cryptococcus neofo ...
Homo sapiens
J. Biol. Chem.
286
34761-34769
2011
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740698
Papadopoulos
Splice variants of the dual sp ...
Homo sapiens, Mus musculus
J. Biol. Chem.
286
5494-5505
2011
2
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2
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1
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8
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741199
Xu
A soybean dual-specificity kin ...
Arabidopsis thaliana, Glycine max
Plant Physiol.
157
2131-2153
2011
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4
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703864
Mazmanian
The zebrafish dyrk1b gene is i ...
Danio rerio
Genesis
48
20-30
2010
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2
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741322
Heizmann
Syk is a dual-specificity kina ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
18563-18568
2010
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2
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701357
Kapitulnik
Pleiotropic functions of biliv ...
Homo sapiens
Trends Pharmacol. Sci.
30
129-137
2009
2
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1
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1
1
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702352
Murakami
Dyrk1A binds to multiple endoc ...
Rattus norvegicus
Biochemistry
48
9297-305
2009
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2
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1
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702562
Koo
QSAR analysis of pyrazolidine- ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
2324-2328
2009
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1
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9
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Activation of Rad53 kinase in ...
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Sequence and analysis of chrom ...
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Sequence characteristics, subc ...
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Transcriptional map of the 2.5 ...
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491607
Bussey
The nucleotide sequence of Sac ...
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532627
Purnelle
The sequence of 32b on the lef ...
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Yeast
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183-188
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Characterization and compariso ...
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Identification of three additi ...
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The murine Dyrk protein maps t ...
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Saren
The sequence of a 36.7 kb segm ...
Saccharomyces cerevisiae
Yeast
13
65-71
1997
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The Dictyostelium dual-specifi ...
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3295-3305
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Purnelle
The sequence of 55 kb on the l ...
Saccharomyces cerevisiae
Yeast
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1483-1492
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Activity and autophosphorylati ...
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532635
Katsoulou
Sequence analysis of a 40.7 kb ...
Saccharomyces cerevisiae
Yeast
12
787-797
1996
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Colwill
The Clk/Sty protein kinase pho ...
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Isolation of human and murine ...
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Shindoh
Cloning of a human homolog of ...
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Guimera
A human homologue of Drosophil ...
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Hum. Mol. Genet.
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Becker
cDNA cloning and characterizat ...
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Dyrk, a dual specificity prote ...
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Duncan
Alternative splicing of STY, a ...
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Tejedor
Minibrain: a new protein kinas ...
Drosophila melanogaster
Neuron
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Lauze
Yeast spindle pole body duplic ...
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MacKintosh
Inhibitors of protein kinases ...
eukaryota
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1994
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Allen
The SAD1/RAD53 protein kinase ...
Saccharomyces cerevisiae
Genes Dev.
8
2401-2415
1994
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Hanes
Characterization by cDNA cloni ...
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Poch
RPK1, an essential yeast prote ...
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Expression of TTK, a novel hum ...
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Multiple cDNAs encoding the es ...
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491354
Stern
Spk1, a new kinase from Saccha ...
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987-1001
1991
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Padmanabha
The KNS1 gene of Saccharomyces ...
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1-9
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532640
Howell
STY, a tyrosine-phosphorylatin ...
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1991
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Ben-David
A mammalian protein kinase wit ...
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1991
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Molecular cloning of a novel h ...
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Hanks
Protein kinase catalytic domai ...
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Tan
Developmentally regulated prot ...
Dictyostelium discoideum
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Garrett
Loss of Ras activity in Saccha ...
Saccharomyces cerevisiae
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