Application | Comment | Organism |
---|---|---|
medicine | role of DYRK3 as an erythropoietic suppressor selectively during stress erythropoiesis, possible candidate for targeting by small molecule inhibitors as potentially important anti-anemia agents | Mus musculus |
Cloned (Comment) | Organism |
---|---|
genomic clones of DYRK3 isolated from a 129svJ Lambda phage library, transgenic mice generated, DYRK3 gene deletion in E14 ES cells using a floxed PGKneo targeting vector, targeted cells injected into C57BL/6J blastocysts, transgenic pA2gata1-DYRK3 mice prepared using an Myc epitope-tagged mDYRK3 cDNA within a pA2gata1 vector | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q922Y0 | wild-type and transgenic mice, C57BL/6J strain, EpoR-HM mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroblast | DYRK3 expression in, ex vivo analysis of erythroid progenitor cells of DYRK3-knockout mice | Mus musculus | - |
testis | DYRK3 expression in | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
increased reticulocyte production in DYRK3-knockout mice in response to hemolytic anemia due to DYRK3 deficiency, elevated reticulocyte and red cell formation in DYRK3-knockout mice after 5-fluorouracil-induced anemia, short term transplant experiments, DYRK3-knockout progenitors support enhanced erythroblast formation, erythropoietic advantages due to DYRK3-deficiency observed in 5-fluorouracil-treated mice expressing a compromised erythropoietin receptor EPOR-HM allele, transgenic pA2gata1-DYRK3 mice produce fewer reticulocytes during hemolytic anemia, pA2gata1-DYRK3 progenitors compromised in late pro-erythroblast formation ex vivo, DYRK3 inhibits transcriptional response pathways mediated by nuclear factor of activated T cells (NFAT) in erythroid K562 cells | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DYRK3 attenuates red cell production selectively during anemia | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DYRK3 | - |
Mus musculus |