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Literature summary for 2.7.12.1 extracted from

  • Kentrup, H.; Becker, W.; Heukelbach, J.; Wilmes, A.; Schurmann, A.; Huppertz, C.; Kainulainen, H.; Joost, H.G.
    Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII (1996), J. Biol. Chem., 271, 3488-3495.
    View publication on PubMed
Search for more literature for 2.7.12.1

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information exchange of two Tyr residues in the activation loop between subdomains VII and VIII for Phe almost completely suppresses the activity and Tyr autophosphorylation of Dyrk. Tyr autophosphorylation is also reduced by exchange of Tyr219 in a tyrosine phosphorylation consensus motif Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + SR protein Rattus norvegicus might be a component of a signaling pathway regulating nuclear functions ADP + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q63470
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation Rattus norvegicus
phosphoprotein dual specificity protein kinase that is regulated by tyrosine phosphorylation in the activation loop Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone recombinant glutathione S-transferase-Dyrk/fusion protein catalyzes histone phosphorylation on tyrosine and Ser/Thr residues Rattus norvegicus ADP + phosphorylated histone
-
 ?
ATP + protein autophosphorylation Rattus norvegicus ADP + phosphoprotein
-
 ?
ATP + SR protein might be a component of a signaling pathway regulating nuclear functions Rattus norvegicus ADP + ?
-
 ?
additional information activity is dependent on tyrosine residues between subdomains VII and VIII Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
dual-specificity tyrosine-phosphorylation regulated kinase 1A
-
 Rattus norvegicus
DYRK
-
 Rattus norvegicus