Literature summary for 2.7.12.1 extracted from

Becker, W.; Weber, Y.; Wetzel, K.; Eirmbter, K.; Tejedor, F.J.; Joost, H.G.
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases (1998), J. Biol. Chem., 273, 25893-25902.

Search for more literature for 2.7.12.1

Cloned(Commentary)

Cloned (Comment)	Organism
fusion protein of DYRK1A accumulates in the nucleus of transfected COS-7 and HEK293 cells, expression in Escherichia coli	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	nuclear localization of DYRK1A is mediated by its nuclear targeting signal, amino acids 105-139, but ist characteristic subnuclear distribution depends on additional N-terminal elements, amino acids 1-104	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43781	-	-
Homo sapiens	Q92630	-	-
Rattus norvegicus	Q63470	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	autophosphorylation	Rattus norvegicus
phosphoprotein	autophosphorylation	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Homo sapiens	-
testis	predominately expressed in testis	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein	autophosphorylation	Rattus norvegicus	ADP + phosphoprotein	-	?
ATP + protein	autophosphorylation	Homo sapiens	ADP + phosphoprotein	-	?
ATP + protein	when expressed in E. coli the enzyme catalyzes autophosphorylation on Tyr residues	Rattus norvegicus	ADP + phosphoprotein	-	?
ATP + protein	when expressed in E. coli the enzyme catalyzes autophosphorylation on Tyr residues	Homo sapiens	ADP + phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
dual-specificity tyrosine-phosphorylation regulated kinase 1A	-	Rattus norvegicus
dual-specificity tyrosine-phosphorylation regulated kinase 2	-	Homo sapiens
dual-specificity tyrosine-phosphorylation regulated kinase 3	-	Homo sapiens
DYRK1A	-	Rattus norvegicus

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Release 2023.1 (January 2023)