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Literature summary for 2.7.12.1 extracted from

  • Pellicioli, A.; Lucca, C.; Liberi, G.; et al.
    Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase (1999), EMBO J., 18, 6561-6572.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of Rad53 in response to DNA damage in G(1) requires the Rad9, Mec3, Ddc1, Rad17 and Rad24 checkpoint factors, while this dependence is greatly reduced in S phase cells. Furthermore, during recovery from checkpoint activation, Rad53 activity decreases through a process that does not require protein synthesis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae required for the execution of checkpoint arrest at multiple stages of the cell cycle. Rad53 modulates the lagging strand replication apparatus by controlling phosphorylation of the DNA polymerase alpha-primase complex in response to intra-S DNA damage ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P22216
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein Rad53 autophosphorylation activity depends on trans phosphorylation mediated by Mec1 and does not require physical association with other proteins Saccharomyces cerevisiae ADP + phosphoprotein
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?
additional information required for the execution of checkpoint arrest at multiple stages of the cell cycle. Rad53 modulates the lagging strand replication apparatus by controlling phosphorylation of the DNA polymerase alpha-primase complex in response to intra-S DNA damage Saccharomyces cerevisiae ?
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?

Synonyms

Synonyms Comment Organism
protein kinase SPK1
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Saccharomyces cerevisiae
Rad53 protein kinase
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Saccharomyces cerevisiae