BRENDA - Enzyme Database
show all sequences of 2.7.11.9

Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130)

Revert-Ros, F.; Lopez-Pascual, E.; Granero-Molto, F.; Macias, J.; Breyer, R.; Zent, R.; Hudson, B.G.; Saadeddin, A.; Revert, F.; Blasco, R.; Navarro, C.; Burks, D.; Saus, J.; J. Biol. Chem. 286, 35030-35043 (2011)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
additional information
gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Mus musculus
the Goodpasture antigen-binding protein performs autophosphorylation
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
additional information
Mus musculus
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
Q9EQG9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
myoblast
GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein performs autophosphorylation
722724
Mus musculus
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
additional information
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
722724
Mus musculus
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Mus musculus
the Goodpasture antigen-binding protein performs autophosphorylation
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
additional information
Mus musculus
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
myoblast
GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein performs autophosphorylation
722724
Mus musculus
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
additional information
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
722724
Mus musculus
?
-
-
-
-
General Information
General Information
Commentary
Organism
physiological function
GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments
Mus musculus
Other publictions for EC 2.7.11.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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