Protein Variants | Comment | Organism |
---|---|---|
additional information | gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Goodpasture antigen-binding protein] | Mus musculus | the Goodpasture antigen-binding protein performs autophosphorylation | ADP + [Goodpasture antigen-binding phosphoprotein] | - |
? | |
additional information | Mus musculus | GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9EQG9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myoblast | GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Goodpasture antigen-binding protein] | the Goodpasture antigen-binding protein performs autophosphorylation | Mus musculus | ADP + [Goodpasture antigen-binding phosphoprotein] | - |
? | |
additional information | GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Goodpasture antigen-binding protein-1 | - |
Mus musculus |
GPBP-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments | Mus musculus |