BRENDA - Enzyme Database show
show all sequences of 2.7.11.9

Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression

Miralem, T.; Gibbs, P.E.; Revert, F.; Saus, J.; Maines, M.D.; J. Biol. Chem. 285, 12551-12558 (2010)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
TNF-alpha
stimulates the autophosphorylation of Goodpasture antigen-binding protein
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
human biliverdin reductase
i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Homo sapiens
the Goodpasture antigen-binding protein performs autophosphorylation
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
Goodpasture antigen-binding protein performs autophosphorylation
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein performs autophosphorylation
722667
Homo sapiens
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
TNF-alpha
stimulates the autophosphorylation of Goodpasture antigen-binding protein
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
human biliverdin reductase
i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Homo sapiens
the Goodpasture antigen-binding protein performs autophosphorylation
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
Goodpasture antigen-binding protein performs autophosphorylation
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein performs autophosphorylation
722667
Homo sapiens
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Expression
Organism
Commentary
Expression
Homo sapiens
TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase
up
General Information
General Information
Commentary
Organism
metabolism
downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
metabolism
downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase
up
Other publictions for EC 2.7.11.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737750
Hanada
Co-evolution of sphingomyelin ...
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Biochim. Biophys. Acta
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1
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287
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1
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6
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1
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2
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1
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3
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1
1
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722724
Revert-Ros
Goodpasture antigen-binding pr ...
Mus musculus
J. Biol. Chem.
286
35030-35043
2011
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1
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722667
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Human biliverdin reductase sup ...
Homo sapiens
J. Biol. Chem.
285
12551-12558
2010
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1
1
1
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704804
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The expression of the Goodpast ...
Rattus norvegicus
J. Chem. Neuroanat.
38
97-105
2009
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1
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4
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693162
Revert
Goodpasture antigen-binding pr ...
Homo sapiens
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30246-30255
2008
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Homo sapiens
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Functional annotation of a ful ...
Mus musculus
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491668
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491669
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Characterization of a novel ty ...
Homo sapiens
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12642-12649
1999
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