BRENDA - Enzyme Database
show all sequences of 2.7.11.9

Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen: identification of novel membrane-bound isoforms

Revert, F.; Ventura, I.; Martinez-Martinez, P.; Granero-Molto, F.; Revert-Ros, F.; Macias, J.; Saus, J.; J. Biol. Chem. 283, 30246-30255 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
isozyme GPBPDELTA26/CERT
Homo sapiens
5829
-
endoplasmic reticulum
91 kDa GPBP
Homo sapiens
5783
-
extracellular
77 kDa GPBP
Homo sapiens
-
-
Golgi apparatus
91 kDa GPBP
Homo sapiens
5794
-
membrane
91 kDa GPBP
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + membrane type IV collagen
Homo sapiens
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
ADP + phopshorylated membrane type IV collagen
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9Y5P4
gene COL4A3BP
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + membrane type IV collagen
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
693162
Homo sapiens
ADP + phopshorylated membrane type IV collagen
-
-
-
?
ATP + membrane type IV collagen
Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen
693162
Homo sapiens
ADP + phopshorylated membrane type IV collagen
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
isozyme GPBPDELTA26/CERT
Homo sapiens
5829
-
endoplasmic reticulum
91 kDa GPBP
Homo sapiens
5783
-
extracellular
77 kDa GPBP
Homo sapiens
-
-
Golgi apparatus
91 kDa GPBP
Homo sapiens
5794
-
membrane
91 kDa GPBP
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + membrane type IV collagen
Homo sapiens
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
ADP + phopshorylated membrane type IV collagen
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + membrane type IV collagen
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
693162
Homo sapiens
ADP + phopshorylated membrane type IV collagen
-
-
-
?
ATP + membrane type IV collagen
Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen
693162
Homo sapiens
ADP + phopshorylated membrane type IV collagen
-
-
-
?
Other publictions for EC 2.7.11.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737750
Hanada
Co-evolution of sphingomyelin ...
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Biochim. Biophys. Acta
1841
704-719
2014
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1
1
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722751
Mencarelli
Goodpasture antigen-binding pr ...
Homo sapiens
J. Biol. Chem.
287
14897-14911
2012
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1
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6
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722724
Revert-Ros
Goodpasture antigen-binding pr ...
Mus musculus
J. Biol. Chem.
286
35030-35043
2011
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722667
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J. Biol. Chem.
285
12551-12558
2010
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704804
Mencarelli
The expression of the Goodpast ...
Rattus norvegicus
J. Chem. Neuroanat.
38
97-105
2009
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693093
Granero-Molto
Goodpasture antigen-binding pr ...
Danio rerio
J. Biol. Chem.
283
20495-20504
2008
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1
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4
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693162
Revert
Goodpasture antigen-binding pr ...
Homo sapiens
J. Biol. Chem.
283
30246-30255
2008
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1
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5
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661708
Granero
A human-specific TNF-responsiv ...
Homo sapiens
FEBS J.
272
5291-5305
2005
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491667
Kawai
Functional annotation of a ful ...
Mus musculus
Nature
409
685-690
2001
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491668
Raya
Goodpasture antigen-binding pr ...
Bos taurus, Homo sapiens, Mus musculus
J. Biol. Chem.
275
40392-40399
2000
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1
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491669
Raya
Characterization of a novel ty ...
Homo sapiens
J. Biol. Chem.
274
12642-12649
1999
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